Abdominal Migraine: An Under-Diagnosed Cause of Recurrent Abdominal Pain in Children

• Published in: Headache 2011-05, Vol.51 (5), p.707-712
• Main Authors: Carson, Laura, Lewis, Donald, Tsou, Marc, McGuire, Erin, Surran, Brooke, Miller, Crystal, Vu, Thuy-Anh
• Format: Article
• Language: English
• Subjects: Abdomen; abdominal migraine; Abdominal Pain - classification; Abdominal Pain - complications; Abdominal Pain - epidemiology; Adolescent; Biological and medical sciences; Bowel disease; Cardiovascular system; Child; Child, Preschool; children; Female; Gastroenterology; Headaches; Humans; Infant; Male; Medical sciences; Medical treatment; Migraine; Migraine Disorders - classification; Migraine Disorders - complications; Migraine Disorders - epidemiology; Neurology; pediatric; Pediatrics; Pharmacology. Drug treatments; Prevalence; United States - epidemiology; Vascular diseases and vascular malformations of the nervous system; Vasodilator agents. Cerebral vasodilators; Young Adult
• ISSN: 0017-8748; 1526-4610
• DOI: 10.1111/j.1526-4610.2011.01855.x

(Headache 2011;51:707‐712) Objective.— Our objective was to demonstrate that, despite recognition by both the gastroenterology and headache communities, abdominal migraine (AM) is an under‐diagnosed cause of chronic, recurrent, abdominal pain in childhood in the USA. Background.— Chronic, recurrent abdominal pain occurs in 9‐15% of all children and adolescents. After exclusion of anatomic, infectious, inflammatory, or other metabolic causes, “functional abdominal pain” is the most common diagnosis of chronic, idiopathic, abdominal pain in childhood. Functional abdominal pain is typically categorized into one, or a combination of, the following 4 groups: functional dyspepsia, irritable bowel syndrome, AM, or functional abdominal pain syndrome. International Classification of Headache Disorders—(ICHD‐2) defines AM as an idiopathic disorder characterized by attacks of midline, moderate to severe abdominal pain lasting 1‐72 hours with vasomotor symptoms, nausea and vomiting, and included AM among the “periodic syndromes of childhood that are precursors for migraine.” Rome III Gastroenterology criteria (2006) separately established diagnostic criteria and confirmed AM as a well‐defined cause of recurrent abdominal pain. Methods.— Following institutional review board approval, a retrospective chart review was conducted on patients referred to an academic pediatric gastroenterology practice with the clinical complaint of recurrent abdominal pain. ICHD‐2 criteria were applied to identify the subset of children fulfilling criteria for AM. Demographics, diagnostic evaluation, treatment regimen and outcomes were collected. Results.— From an initial cohort of 600 children (ages 1‐21 years; 59% females) with recurrent abdominal pain, 142 (24%) were excluded on the basis of their ultimate diagnosis. Of the 458 patients meeting inclusion criteria, 1824 total patient office visits were reviewed. Three hundred eighty‐eight (84.6%) did not meet criteria for AM, 20 (4.4%) met ICHD‐2 formal criteria for AM and another 50 (11%) had documentation lacking at least 1 criterion, but were otherwise consistent with AM (probable AM). During the observation period, no children seen in this gastroenterology practice had received a diagnosis of AM. Conclusion.— Among children with chronic, idiopathic, recurrent abdominal pain, AM represents about 4‐15%. Given the spectrum of treatment modalities now available for pediatric migraine, increased awareness of cardinal features of AM by pedi