Controlled synthesis of Pt nanoparticles array through electroreduction of cisplatin bound at nucleobases terminated surface and application into H2O2 sensing

Fabrication of sub-monolayer array of Pt nanoparticles (PtNPs) assembled at nucleobases terminated layers and their application into H(2)O(2) and glucose sensing were reported. To prepare such a PtNPs assembly, 3-mercaptopropionic acid (MPA), Zr(4+), nucleotide-5'-monophosphate (NTMP including...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2011-01, Vol.26 (5), p.2067-2073
Main Authors: Ji, Shujun, Guo, Qingqing, Yue, Qiaoli, Wang, Lei, Wang, Huaisheng, Zhao, Jinsheng, Dong, Ruixin, Liu, Jifeng, Jia, Jianbo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques - instrumentation
Biotechnology
Cisplatin - chemistry
Conductometry - instrumentation
Electrodes
Electroplating - methods
Equipment Design
Equipment Failure Analysis
Fundamental and applied biological sciences. Psychology
Glucose - analysis
Hydrogen Peroxide - analysis
Hydrogen Peroxide - chemistry
Nanoparticles - chemistry
Nanotechnology - instrumentation
Nucleic Acids - chemistry
Oxidation-Reduction
Platinum - chemistry
Protein Binding
Surface Properties
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Summary:Fabrication of sub-monolayer array of Pt nanoparticles (PtNPs) assembled at nucleobases terminated layers and their application into H(2)O(2) and glucose sensing were reported. To prepare such a PtNPs assembly, 3-mercaptopropionic acid (MPA), Zr(4+), nucleotide-5'-monophosphate (NTMP including guanosine, adenosine, cytidine, uridine-5'-monophosphate, and abbreviations were GMP, AMP, CMP, UMP, respectively) were adsorbed onto Au substrate sequentially to form nucleobases terminated surface and Zr(4+) acted as binder to link carboxylic and phosphoric groups (NTMP/Zr(4+)/MPA/Au). Complexation of cisplatin, cis-Pt(NH(3))(2)Cl(2), with terminated nucleobases and following electrochemical reduction of surface-bound cisplatin gave PtNPs attached surface. Different PtNPs coverage or particle density was obtained depending on the NTMP used and decreased in the order: PtNPs/GMP/Zr(4+)/MPA/Au>PtNPs/AMP/Zr(4+)/MPA/Au>PtNPs/CMP/Zr(4+)/MPA/Au>PtNPs/UMP/Zr(4+)/MPA/Au. The surface loading of Pt was between 160 and 16 ng/cm(2). The as prepared PtNPs can be used as electrocatalysts for H(2)O(2) sensing (detection limit of H(2)O(2)
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2010.09.003