Pharmacology of receptor operated calcium entry in human neutrophils

In neutrophils, increases in intracellular calcium [Ca2+]i provide a crucial link between inflammatory mediators and inflammatory responses. The modulation of [Ca2+]i fluxes in non-excitable cells such as neutrophils has been studied for more than 25years yet remains to be resolved. In these cells,...

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Bibliographic Details
Published in:International immunopharmacology 2011-02, Vol.11 (2), p.145-148
Main Authors: Salmon, Michael D., Ahluwalia, Jatinder
Format: Article
Language:English
Subjects:
Antagonists
Azepines - pharmacology
Biological and medical sciences
Boron Compounds - pharmacology
Calcium - metabolism
Calcium Channels - metabolism
Calcium Signaling - drug effects
Calcium Signaling - physiology
Gadolinium - pharmacology
Humans
Medical sciences
Neutrophil
Neutrophils - drug effects
Neutrophils - immunology
Neutrophils - metabolism
Pharmacology. Drug treatments
Receptor operated calcium entry
Store operated calcium entry
Strontium - pharmacology
Thapsigargin
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Summary:In neutrophils, increases in intracellular calcium [Ca2+]i provide a crucial link between inflammatory mediators and inflammatory responses. The modulation of [Ca2+]i fluxes in non-excitable cells such as neutrophils has been studied for more than 25years yet remains to be resolved. In these cells, the Ca2+ influx can occur through at least two mechanisms, as follows: one dependent on the state of filling of the endoplasmic reticulum Ca2+ stores, termed store operated calcium entry (SOCE), and the other less studied mechanism in neutrophils which is not dependent on the state of the Ca2+ stores but is regulated by receptor occupation, termed receptor operated calcium entry (ROCE). Over the past tenyears, the molecular components of SOCE have been extensively characterized, but in neutrophils, the molecular components of ROCE have only recently been explored. In this review, we discuss recent research findings that have demonstrated an important role for ROCE in human neutrophils. In addition, an overview of pharmacological approaches used to discriminate between ROCE and SOCE will be discussed. The elucidation of the molecular components of ROCE may well provide important pharmacological targets for the development of novel anti-inflammatory drugs.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2010.11.006