Unexpected arousal, anxiety sensitivity, and their interaction on CO2 -induced panic: Further evidence for the context-sensitivity vulnerability model

Highlights ► This experiment tested predictions from the context-sensitivity model of panic. ► Subjects’ high in anxiety sensitivity (AS) were more likely to show greater fear responding to 35% CO2 inhalation relative to subjects low in anxiety sensitivity, however this relationship was strongly mod...

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Bibliographic Details
Published in:Journal of anxiety disorders 2011-06, Vol.25 (5), p.645-653
Main Authors: Telch, Michael J, Harrington, Patrick J, Smits, Jasper A.J, Powers, Mark B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Analysis of Variance
Anxiety
Anxiety - physiopathology
Anxiety - psychology
Anxiety disorders. Neuroses
Arousal
Arousal - physiology
Biological and medical sciences
Carbon Dioxide
Female
Heart Rate - physiology
Humans
Male
Medical sciences
Panic
Panic - physiology
Panic disorder
Personality Inventory
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Relaxation
Sensitivity
Stress, Psychological - physiopathology
Stress, Psychological - psychology
Surveys and Questionnaires
Vital Capacity - physiology
Vulnerability
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Summary:Highlights ► This experiment tested predictions from the context-sensitivity model of panic. ► Subjects’ high in anxiety sensitivity (AS) were more likely to show greater fear responding to 35% CO2 inhalation relative to subjects low in anxiety sensitivity, however this relationship was strongly moderated by the experimental manipulation of threat context. ► High AS subjects who were led to expect that 35% CO2 inhalation would produce feelings of relaxation showed markedly greater fear and probability of panic relative to High AS subjects who were led to expect heightened arousal. ► As predicted, subjects low in AS were unaffected by the manipulation of the “unexpectedness” of CO2 effects. ► These findings provide additional support for the role of context in moderating the effects of anxiety sensitivity on fear responding to biological challenge.
ISSN:0887-6185
1873-7897
DOI:10.1016/j.janxdis.2011.02.005