Is intractable epilepsy a tauopathy?

Abstract Tau exists in neuronal axons and glial cells of the central nervous system and contributes to the maintenance of the unique cell morphology. It functions in axon elongation, cell polarity formation and microtubule stabilization. Aggregates and hyper-phosphorylated tau proteins are classical...

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Bibliographic Details
Published in:Medical hypotheses 2011-06, Vol.76 (6), p.897-900
Main Authors: Xi, Zhi-Qin, Wang, Xue-Feng, Shu, Xiao-Fang, Chen, Guo-Jun, Xiao, Fei, Sun, Ji-Jun, Zhu, Xi
Format: Article
Language:English
Subjects:
Epilepsy - metabolism
Humans
Internal Medicine
tau Proteins - metabolism
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Summary:Abstract Tau exists in neuronal axons and glial cells of the central nervous system and contributes to the maintenance of the unique cell morphology. It functions in axon elongation, cell polarity formation and microtubule stabilization. Aggregates and hyper-phosphorylated tau proteins are classical components of neurofibrillary lesions in numerous neurodegenerative disorders, which are called “tauopathies”. Recent studies have demonstrated that tau-associated genes and proteins and tau phosphorylation were abnormal in intractable epilepsy. Therefore, the discovery of the dysfunctional tau in intractable epilepsy opens a new window in the study of central tauopathy.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2011.03.003