Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner

Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant ad...

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Bibliographic Details
Published in:European journal of pharmacology 2011-06, Vol.660 (1), p.148-155
Main Authors: de Backer, Marijke W.A., la Fleur, Susanne E., Adan, Roger A.H.
Format: Article
Language:English
Subjects:
Agouti-related peptide
Agouti-Related Protein - genetics
Agouti-Related Protein - metabolism
Animals
Biological and medical sciences
Brain
Data processing
Energy balance
Gene Expression
Humans
Hypothalamic Area, Lateral - metabolism
Hypothalamus
Hypothalamus (lateral)
Injections
Medical sciences
Melanocortin
Metabolic diseases
Neuropeptide Y
Neuropeptide Y - genetics
Neuropeptide Y - metabolism
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - physiopathology
Organ Specificity
Paraventricular Hypothalamic Nucleus - metabolism
Paraventricular nucleus
Peptide Fragments - genetics
Peptide Fragments - metabolism
pharmacology
Pharmacology. Drug treatments
Recombinant adeno-associated viral vectors
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Summary:Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant adeno-associated viral vectors that overexpressed agouti-related peptide or neuropeptide Y in specific brain regions namely the paraventricular nucleus and the lateral hypothalamus. In this review we compare the results from these studies and discuss these data with previous data from intracerebroventricular or local brain injections. This review shows that the effects of agouti-related peptide clearly differ from those of neuropeptide Y. In addition, these data suggests complementary roles for these neuropeptides in energy balance.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2010.12.021