Can MRI Predict Local Control Rate of Uterine Cervical Cancer Immediately after Radiation Therapy?

Purpose: To evaluate the utility of measuring the volumes of areas of high signal intensity on T2-weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer. Materials and Methods: From our departmental database, we identifi...

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Published in:Magnetic Resonance in Medical Sciences 2010, Vol.9(3), pp.141-148
Main Authors: SAIDA, Tsukasa, TANAKA, Yumiko OISHI, OHARA, Kiyoshi, OKI, Akinori, SATO, Toyomi, YOSHIKAWA, Hiroyuki, MINAMI, Manabu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cervical cancer
Contrast Media
Female
Humans
local control
Magnetic Resonance Imaging
Middle Aged
Neoplasm Recurrence, Local
prognosis
radiation therapy
Radiotherapy Dosage
Sensitivity and Specificity
Tumor Burden
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
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Summary:Purpose: To evaluate the utility of measuring the volumes of areas of high signal intensity on T2-weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer. Materials and Methods: From our departmental database, we identified 109 patients with cervical cancer who underwent MR imaging before irradiation and just before or just after completion of radiation therapy from 1994 to 2007. We included 46 of the 109 patients in this study, 5 patients with local recurrence and 41 patients who were free of disease for more than 2 years. Fifteen received radiation therapy alone, and 28 patients received concurrent chemoradiation therapy. We measured the volumes of areas of high signal intensity involving the uterine cervix on T2-weighted MR images before radiation therapy and just before or just after its completion. We measured the 3 orthogonal diameters to calculate the volume as an ellipsoid and evaluated proportional tumor volume and the rate of reduction. We analyzed statistics with Student's t-test. Results: In patients with local recurrence, the mean volume of the areas of high signal intensity on T2-weighted MR images just before completion of irradiation therapy or just after was 19.70 cm3, which was significantly larger than that in patients without recurrence (1.77 cm3, P
ISSN:1347-3182
1880-2206
1880-2206
DOI:10.2463/mrms.9.141