Analysis of Polar Organic Compounds Using Charge Exchange Ionization and Membrane Introduction Mass Spectrometry

• Published in: Analytical chemistry (Washington) 1996-07, Vol.68 (13), p.2097-2101
• Main Authors: Cisper, M. E, Garrett, A. W, Cameron, D, Hemberger, P. H
• Format: Article
• Language: English
• Subjects: Analytical chemistry; Chemistry; Exact sciences and technology; Ions; Membranes; Scientific imaging; Spectrometric and optical methods
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/ac960039f

Charge exchange ionization in conjunction with membrane introduction mass spectrometry provides a sensitive method for the detection of polar volatile organic compounds and semivolatile compounds in air. Sample introduction into an ion trap mass spectrometer was accomplished with a hollow fiber silicone membrane assembly. Atmospheric oxygen, which diffuses through the membrane, was used as the charge exchange reagent. Chemical ionization parameters were optimized using methyl ethyl ketone (2-butanone) standards in air. Several other oxygen-containing compounds, including acetone (2-propanone), methyl isobutyl ketone (4-methyl-2-pentanone), propanal, isopropyl alcohol (2-propanol), cyclohexanol, dimethyl sulfoxide (sulfinylbismethane), 2-(diethylamino)ethanol, and dimethyl methylphosphonate were analyzed with this technique. This method was used to obtain mass spectra for a variety of classes of compounds and produced a 4−20-fold improvement in response for all of the polar compounds we examined when compared to signal obtained from electron ionization.