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Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients
Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients...
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| Published in: | Endocrine pathology 2011-06, Vol.22 (2), p.58-65 |
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| container_title | Endocrine pathology |
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| creator | Ozdemir, Didem Ersoy, Reyhan Cuhaci, Neslihan Arpaci, Dilek Ersoy, Eren P. Korukluoglu, Birol Guler, Gulnur Cakir, Bekir |
| description | Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Preoperative thyroid functions, thyroid autoantibodies, ultrasonographical features, cytology, and histopathology results of 354 (79.9%) CPTC and 90 (20.3%) FVPTC patients were reviewed retrospectively. Sex distribution, mean age, thyroid autoantibody positivity, and thyroid dysfunctions were similar in two groups. Among 320 patients with preoperative ultrasonography (US) findings, a hypoechoic halo was observed more frequently (
p
= 0.003), and marginal irregularity was observed less commonly (
p
= 0.024) in FVPTC lesions. In CPTC, rate of malignant cytology (
p
= 0.001), and in FVPTC, rate of suspicious cytology (
p
|
| doi_str_mv | 10.1007/s12022-011-9160-0 |
| format | article |
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p
= 0.003), and marginal irregularity was observed less commonly (
p
= 0.024) in FVPTC lesions. In CPTC, rate of malignant cytology (
p
= 0.001), and in FVPTC, rate of suspicious cytology (
p
< 0.001) were significantly higher. Histopathologically, mean tumor diameter was markedly higher in FVPTC compared to CPTC (16.89 ± 13.86 vs 10.64 ± 9.70 mm,
p
< 0.001), while capsular invasion and extrathyroidal spread were significantly lower in patients with FVPTC (
p
= 0.018 and
p
= 0.039, respectively). FVPTC tend to have more benign features in US and less malignant results in cytology. Higher tumor size in FVPTC might be explained by the recognition of clinical importance of these lesions after reaching particular sizes due to benign US features.</description><identifier>ISSN: 1046-3976</identifier><identifier>EISSN: 1559-0097</identifier><identifier>DOI: 10.1007/s12022-011-9160-0</identifier><identifier>PMID: 21556739</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Biopsy, Fine-Needle ; Carcinoma ; Carcinoma, Papillary ; Carcinoma, Papillary, Follicular - diagnosis ; Carcinoma, Papillary, Follicular - metabolism ; Endocrinology ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neoplasm Invasiveness ; Oncology ; Pathology ; Retrospective Studies ; Sex Factors ; Thyroid Cancer, Papillary ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - pathology ; Thyroid Hormones - blood ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - metabolism ; Ultrasonography</subject><ispartof>Endocrine pathology, 2011-06, Vol.22 (2), p.58-65</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-338b905464f0a86538b31c6b0ff6cf799d92fa3b40de2005770ae221fd6a8e823</citedby><cites>FETCH-LOGICAL-c370t-338b905464f0a86538b31c6b0ff6cf799d92fa3b40de2005770ae221fd6a8e823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21556739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cuhaci, Neslihan</creatorcontrib><creatorcontrib>Arpaci, Dilek</creatorcontrib><creatorcontrib>Ersoy, Eren P.</creatorcontrib><creatorcontrib>Korukluoglu, Birol</creatorcontrib><creatorcontrib>Guler, Gulnur</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><title>Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients</title><title>Endocrine pathology</title><addtitle>Endocr Pathol</addtitle><addtitle>Endocr Pathol</addtitle><description>Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Preoperative thyroid functions, thyroid autoantibodies, ultrasonographical features, cytology, and histopathology results of 354 (79.9%) CPTC and 90 (20.3%) FVPTC patients were reviewed retrospectively. Sex distribution, mean age, thyroid autoantibody positivity, and thyroid dysfunctions were similar in two groups. Among 320 patients with preoperative ultrasonography (US) findings, a hypoechoic halo was observed more frequently (
p
= 0.003), and marginal irregularity was observed less commonly (
p
= 0.024) in FVPTC lesions. In CPTC, rate of malignant cytology (
p
= 0.001), and in FVPTC, rate of suspicious cytology (
p
< 0.001) were significantly higher. Histopathologically, mean tumor diameter was markedly higher in FVPTC compared to CPTC (16.89 ± 13.86 vs 10.64 ± 9.70 mm,
p
< 0.001), while capsular invasion and extrathyroidal spread were significantly lower in patients with FVPTC (
p
= 0.018 and
p
= 0.039, respectively). FVPTC tend to have more benign features in US and less malignant results in cytology. Higher tumor size in FVPTC might be explained by the recognition of clinical importance of these lesions after reaching particular sizes due to benign US features.</description><subject>Adult</subject><subject>Biopsy, Fine-Needle</subject><subject>Carcinoma</subject><subject>Carcinoma, Papillary</subject><subject>Carcinoma, Papillary, Follicular - diagnosis</subject><subject>Carcinoma, Papillary, Follicular - metabolism</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Invasiveness</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Ultrasonography</subject><issn>1046-3976</issn><issn>1559-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kc1u3CAUha2qVfPTPkA3Feqmm7q5gA2mu8jqJJUiNYukW8TYMEOEwQW8mAfqe4aRk1aqlBXcw3fPBU5VfcDwFQPwi4QJEFIDxrXADGp4VZ3ithU1gOCvyx4aVlPB2Ul1ltIDAKYA5G11QgrFOBWn1Z_eqZTsoBxSfkSb4JwdFqci-qWiVT6jWzVbV4QDutsfYrAj6lUcrA-T-ob6MM2FS8GjYFDvrD9afUH3LkdV1LCLat6vWn_IwYXdWhyHXduUw6zy_llGG63yEnVC1qOmacrsbLXP6V31xiiX9Pun9by633y_66_rm59XP_rLm3qgHHJNabcV0DasMaA61paS4oFtwRg2GC7EKIhRdNvAqAlAyzkoTQg2I1Od7gg9rz6vvnMMvxedspxsGnR5vtdhSbLjQETLmCjkp__Ih7BEXy4nOyZaQRpMC4RXaIghpaiNnKOdyldKDPKYoFwTlCVBeUxQQun5-GS8bCc9_u14jqwAZAVSOfI7Hf9Nftn1Eftwp8s</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Ozdemir, Didem</creator><creator>Ersoy, Reyhan</creator><creator>Cuhaci, Neslihan</creator><creator>Arpaci, Dilek</creator><creator>Ersoy, Eren P.</creator><creator>Korukluoglu, Birol</creator><creator>Guler, Gulnur</creator><creator>Cakir, Bekir</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients</title><author>Ozdemir, Didem ; Ersoy, Reyhan ; Cuhaci, Neslihan ; Arpaci, Dilek ; Ersoy, Eren P. ; Korukluoglu, Birol ; Guler, Gulnur ; Cakir, Bekir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-338b905464f0a86538b31c6b0ff6cf799d92fa3b40de2005770ae221fd6a8e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biopsy, Fine-Needle</topic><topic>Carcinoma</topic><topic>Carcinoma, Papillary</topic><topic>Carcinoma, Papillary, Follicular - diagnosis</topic><topic>Carcinoma, Papillary, Follicular - metabolism</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozdemir, Didem</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Cuhaci, Neslihan</creatorcontrib><creatorcontrib>Arpaci, Dilek</creatorcontrib><creatorcontrib>Ersoy, Eren P.</creatorcontrib><creatorcontrib>Korukluoglu, Birol</creatorcontrib><creatorcontrib>Guler, Gulnur</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozdemir, Didem</au><au>Ersoy, Reyhan</au><au>Cuhaci, Neslihan</au><au>Arpaci, Dilek</au><au>Ersoy, Eren P.</au><au>Korukluoglu, Birol</au><au>Guler, Gulnur</au><au>Cakir, Bekir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients</atitle><jtitle>Endocrine pathology</jtitle><stitle>Endocr Pathol</stitle><addtitle>Endocr Pathol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>22</volume><issue>2</issue><spage>58</spage><epage>65</epage><pages>58-65</pages><issn>1046-3976</issn><eissn>1559-0097</eissn><abstract>Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Preoperative thyroid functions, thyroid autoantibodies, ultrasonographical features, cytology, and histopathology results of 354 (79.9%) CPTC and 90 (20.3%) FVPTC patients were reviewed retrospectively. Sex distribution, mean age, thyroid autoantibody positivity, and thyroid dysfunctions were similar in two groups. Among 320 patients with preoperative ultrasonography (US) findings, a hypoechoic halo was observed more frequently (
p
= 0.003), and marginal irregularity was observed less commonly (
p
= 0.024) in FVPTC lesions. In CPTC, rate of malignant cytology (
p
= 0.001), and in FVPTC, rate of suspicious cytology (
p
< 0.001) were significantly higher. Histopathologically, mean tumor diameter was markedly higher in FVPTC compared to CPTC (16.89 ± 13.86 vs 10.64 ± 9.70 mm,
p
< 0.001), while capsular invasion and extrathyroidal spread were significantly lower in patients with FVPTC (
p
= 0.018 and
p
= 0.039, respectively). FVPTC tend to have more benign features in US and less malignant results in cytology. Higher tumor size in FVPTC might be explained by the recognition of clinical importance of these lesions after reaching particular sizes due to benign US features.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21556739</pmid><doi>10.1007/s12022-011-9160-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Biopsy, Fine-Needle Carcinoma Carcinoma, Papillary Carcinoma, Papillary, Follicular - diagnosis Carcinoma, Papillary, Follicular - metabolism Endocrinology Female Humans Male Medicine Medicine & Public Health Neoplasm Invasiveness Oncology Pathology Retrospective Studies Sex Factors Thyroid Cancer, Papillary Thyroid Gland - diagnostic imaging Thyroid Gland - pathology Thyroid Hormones - blood Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism Ultrasonography |
| title | Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients |
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