Characterization of drug–cyclodextrin formulations using Raman mapping and multivariate curve resolution

Raman chemical imaging was used in the characterization of drug–excipient interactions between a drug and different types of cyclodextrins. Detailed analysis was carried out regarding the interactions between the active ingredient (API) and the cyclodextrins and the heterogeneity of the samples was...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2011-08, Vol.56 (1), p.38-44
Main Authors: Vajna, Balázs, Farkas, István, Farkas, Attila, Pataki, Hajnalka, Nagy, Zsombor, Madarász, János, Marosi, György
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemistry, Pharmaceutical
Chemometrics
Crystallinity
Crystallization
Cyclodextrin
Cyclodextrins - chemistry
Excipients - chemistry
Fundamental and applied biological sciences. Psychology
General pharmacology
Hyperspectral imaging
Linear Models
Medical sciences
Micro-Raman
Microscopy, Electron, Scanning
Multivariate Analysis
Pharmaceutical
Pharmaceutical Preparations - chemistry
Pharmacology. Drug treatments
Reproducibility of Results
Spectrometry, X-Ray Emission
Spectrum Analysis, Raman
X-Ray Diffraction
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Summary:Raman chemical imaging was used in the characterization of drug–excipient interactions between a drug and different types of cyclodextrins. Detailed analysis was carried out regarding the interactions between the active ingredient (API) and the cyclodextrins and the heterogeneity of the samples was studied using multivariate curve resolution–alternating least squares algorithm. The amount of recrystallized pure API was also estimated using the same curve resolution method. The Raman mapping results were validated via scanning electron microscopy–energy dispersive X-ray spectroscopy and X-ray powder diffraction. Raman mapping was found to be suitable to detect traces of pure crystalline API below the detection limit of X-ray powder diffraction.
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2011.05.005