Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia

Background Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic pa...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental nephrology 2011-06, Vol.15 (3), p.391-397
Main Authors: Tanaka, Kentaro, Hara, Shigeko, Kushiyama, Akifumi, Ubara, Yoshifumi, Yoshida, Yoko, Mizuiri, Sonoo, Aikawa, Atsushi, Kawatzu, Shouji
Format: Article
Language:English
Subjects:
Aged
Arteriosclerosis Obliterans - etiology
Coronary Disease - etiology
Diabetes Mellitus, Type 2 - complications
Diabetic Nephropathies - epidemiology
Female
Glomerular Filtration Rate
Humans
Hyperuricemia - complications
Japan - epidemiology
Kidney Diseases - complications
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original Article
Prevalence
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Stroke - etiology
Urology
Vascular Diseases - epidemiology
Vascular Diseases - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Although a high prevalence of macrovascular disease (MVD) has been reported in patients with stage 3 chronic kidney disease (CKD), few studies have reported its risk with respect to the underlying cause of kidney disease. This study investigated the prevalence of MVD in type 2 diabetic patients with CKD stratified by CKD stage, as defined by estimated glomerular filtration rate (eGFR), as well as the risk factors for MVD. Methods 1493 patients with diabetic CKD (1273 males, 220 females) were stratified by CKD stage (stage 1: 39, stage 2: 272, stage 3: 1052, stage 4: 101, stage 5: 29) based on eGFR calculated by the Japanese formula and averaged over 8 months. MVD was defined as one of the following: coronary heart disease (CHD), stroke or arteriosclerosis obliterans (ASO). Results The prevalence of MVD was 18.6%. A significant increasing trend in MVD prevalence was observed from stage 3 (17.78%) to 4 (52.48%). According to a receiver operating characteristic curve analysis on MVD prevalence in stage 3 patients, an eGFR of 46.4 ml/min/1.73 m 2 was determined to be a critical cut-off level. Proteinuria, eGFR
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-011-0420-6