Rocuronium and sugammadex for rapid sequence induction of obstetric general anaesthesia

• Published in: Acta anaesthesiologica Scandinavica 2011-07, Vol.55 (6), p.694-699
• Main Authors: WILLIAMSON, R. M., MALLAIAH, S., BARCLAY, P.
• Format: Article
• Language: English
• Subjects: Adult; Androstanols - pharmacology; Anesthesia; Anesthesia, General; Anesthesia, Obstetrical; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Female; gamma-Cyclodextrins - pharmacology; Humans; Intubation, Intratracheal; Medical sciences; Neuromuscular Nondepolarizing Agents - pharmacology; Pregnancy; Prospective Studies; Time Factors
• ISSN: 0001-5172; 1399-6576
• DOI: 10.1111/j.1399-6576.2011.02431.x

Background: Many anaesthetists use rocuronium in place of suxamethonium for rapid sequence induction (RSI). This is less common in obstetric anaesthesia as the duration of action of an effective dose of rocuronium exceeds most obstetric procedures. Sugammadex offers the possibility of rapidly reversing profound rocuronium neuromuscular blockade at the end of surgery. We aimed to determine whether rocuronium 1.2 mg/kg used for RSI in the obstetric population would provide good intubating conditions at 60 s and would be effectively reversed by sugammadex at the end of surgery. Methods: We present a prospective series of 18 patients who received rocuronium 1.2 mg/kg at induction of anaesthesia, monitored with a train‐of‐four ratio (TOF)‐Watch SX®, and reversed using sugammadex 4 mg/kg. Results: The mean (95% CI) onset time of rocuronium was 71 (56–86) s, and the mean (95% CI) time to recovery of the TOF to ≥90%, after the administration of sugammadex 4 mg/kg at the end of surgery, was 86 (69–104) s. Conclusion: Rocuronium 1.2 mg/kg reversed by sugammadex appears to be effective in the obstetric population.