Loading…
Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial
The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hos...
Saved in:
| Published in: | European journal of applied physiology 2011-07, Vol.111 (7), p.1437-1445 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903 |
| container_end_page | 1445 |
| container_issue | 7 |
| container_start_page | 1437 |
| container_title | European journal of applied physiology |
| container_volume | 111 |
| creator | Cheema, Birinder Singh Bobby Abas, Haifa Smith, Benjamin C. F. O’Sullivan, Anthony J. Chan, Maria Patwardhan, Aditi Kelly, John Gillin, Adrian Pang, Glen Lloyd, Brad Berger, Klaus Baune, Bernhard T. Fiatarone Singh, Maria A. |
| description | The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital, Sydney, Australia. Patients were randomized to: PRT + usual care (
n
= 24) or usual care control (
n
= 25). The PRT group performed two sets of 10 exercises at high intensity using free-weights, 3 times per week for 12 weeks during dialysis, while the control group did not exercise. Tumor necrosis factor-alpha, interleukin-1b, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, and interleukin-12 were measured in serum before and after the intervention period. Muscle cross-sectional area (CSA), intramuscular lipid, intermuscular adipose tissue, and subcutaneous and total thigh fat, evaluated via computed tomography of the non-dominant mid-thigh, were also collected at both time points. All cytokines were significantly elevated in the total cohort at baseline compared with normative data. There were no cytokine changes over time or between groups (
p
> 0.05). In secondary analyses pooling the groups, changes in logIL-6 and IL-8 were inversely related to changes subcutaneous thigh fat (
p
|
| doi_str_mv | 10.1007/s00421-010-1763-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_871968705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1034809533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903</originalsourceid><addsrcrecordid>eNp9kUuLFTEQhYMozjj6A9xIEEQ3rXmn250M4wMG3Oi6ya2uaMbu5JqkF9dfb5p7nQFBV1UhX52cyiHkKWevOWP2TWFMCd4xzjpujez0PXLOlRw6I4W9f9vz4Yw8KuWGMdYL3j8kZ4Jzw4XR5yRceY9QafI0YwmlughIa3YhhviNTmveyndc0hTcfGgETZFCyLDOrm53cKjpR4hY3lJHs4tTWsIvnCikWHOa59bW3GYfkwfezQWfnOoF-fr-6svlx-7684dPl--uO1BS1o5PwnkAvWMgcWeF92YCK0AgKublYPTklUJvYbAOdx5c29VrDcYa5QcmL8jLo-4-p58rljouoQDOs4uY1jL2lg-mt0w38tV_Sc6k6tmgpWzo87_Qm7Tm2PbY9LRWlvcN4kcIciolox_3OSwuH5rSuAU2HgMb2XZugY2bh2cn4XW34HQ78SehBrw4Aa6Am337YQjljlNiaCZN48SRK_stMsx3Dv_9-m8SGK8Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>871554718</pqid></control><display><type>article</type><title>Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial</title><source>Springer Link</source><creator>Cheema, Birinder Singh Bobby ; Abas, Haifa ; Smith, Benjamin C. F. ; O’Sullivan, Anthony J. ; Chan, Maria ; Patwardhan, Aditi ; Kelly, John ; Gillin, Adrian ; Pang, Glen ; Lloyd, Brad ; Berger, Klaus ; Baune, Bernhard T. ; Fiatarone Singh, Maria A.</creator><creatorcontrib>Cheema, Birinder Singh Bobby ; Abas, Haifa ; Smith, Benjamin C. F. ; O’Sullivan, Anthony J. ; Chan, Maria ; Patwardhan, Aditi ; Kelly, John ; Gillin, Adrian ; Pang, Glen ; Lloyd, Brad ; Berger, Klaus ; Baune, Bernhard T. ; Fiatarone Singh, Maria A.</creatorcontrib><description>The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital, Sydney, Australia. Patients were randomized to: PRT + usual care (
n
= 24) or usual care control (
n
= 25). The PRT group performed two sets of 10 exercises at high intensity using free-weights, 3 times per week for 12 weeks during dialysis, while the control group did not exercise. Tumor necrosis factor-alpha, interleukin-1b, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, and interleukin-12 were measured in serum before and after the intervention period. Muscle cross-sectional area (CSA), intramuscular lipid, intermuscular adipose tissue, and subcutaneous and total thigh fat, evaluated via computed tomography of the non-dominant mid-thigh, were also collected at both time points. All cytokines were significantly elevated in the total cohort at baseline compared with normative data. There were no cytokine changes over time or between groups (
p
> 0.05). In secondary analyses pooling the groups, changes in logIL-6 and IL-8 were inversely related to changes subcutaneous thigh fat (
p
< 0.05) while changes in logIL-6 were also inversely related to changes in thigh muscle CSA, and total thigh fat (
p
< 0.03). These data suggest that 12 weeks of intradialytic progressive resistance training does not improve circulating pro- and anti-inflammatory markers. Further research is required to elucidate the implications and mechanisms of the relationships between IL-6 and IL-8 and body composition in ESRD.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-010-1763-5</identifier><identifier>PMID: 21161265</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adipose tissue ; Aged ; Algorithms ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Body composition ; Chronic illnesses ; Clinical trials ; Cytokines ; Cytokines - blood ; Cytokines - metabolism ; Exercise - physiology ; Exercise Therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodialysis ; Hospitals ; Human Physiology ; Humans ; Kidney diseases ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Male ; Medicine ; Middle Aged ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Nutrition ; Occupational Medicine/Industrial Medicine ; Original Article ; Quality of life ; Renal Dialysis ; Resistance Training ; Sports Medicine ; Strength training ; Treatment Outcome ; Tumor necrosis factor-TNF ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports ; Weight control</subject><ispartof>European journal of applied physiology, 2011-07, Vol.111 (7), p.1437-1445</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903</citedby><cites>FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24294806$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21161265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheema, Birinder Singh Bobby</creatorcontrib><creatorcontrib>Abas, Haifa</creatorcontrib><creatorcontrib>Smith, Benjamin C. F.</creatorcontrib><creatorcontrib>O’Sullivan, Anthony J.</creatorcontrib><creatorcontrib>Chan, Maria</creatorcontrib><creatorcontrib>Patwardhan, Aditi</creatorcontrib><creatorcontrib>Kelly, John</creatorcontrib><creatorcontrib>Gillin, Adrian</creatorcontrib><creatorcontrib>Pang, Glen</creatorcontrib><creatorcontrib>Lloyd, Brad</creatorcontrib><creatorcontrib>Berger, Klaus</creatorcontrib><creatorcontrib>Baune, Bernhard T.</creatorcontrib><creatorcontrib>Fiatarone Singh, Maria A.</creatorcontrib><title>Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital, Sydney, Australia. Patients were randomized to: PRT + usual care (
n
= 24) or usual care control (
n
= 25). The PRT group performed two sets of 10 exercises at high intensity using free-weights, 3 times per week for 12 weeks during dialysis, while the control group did not exercise. Tumor necrosis factor-alpha, interleukin-1b, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, and interleukin-12 were measured in serum before and after the intervention period. Muscle cross-sectional area (CSA), intramuscular lipid, intermuscular adipose tissue, and subcutaneous and total thigh fat, evaluated via computed tomography of the non-dominant mid-thigh, were also collected at both time points. All cytokines were significantly elevated in the total cohort at baseline compared with normative data. There were no cytokine changes over time or between groups (
p
> 0.05). In secondary analyses pooling the groups, changes in logIL-6 and IL-8 were inversely related to changes subcutaneous thigh fat (
p
< 0.05) while changes in logIL-6 were also inversely related to changes in thigh muscle CSA, and total thigh fat (
p
< 0.03). These data suggest that 12 weeks of intradialytic progressive resistance training does not improve circulating pro- and anti-inflammatory markers. Further research is required to elucidate the implications and mechanisms of the relationships between IL-6 and IL-8 and body composition in ESRD.</description><subject>Adipose tissue</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body composition</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Exercise - physiology</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nutrition</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Quality of life</subject><subject>Renal Dialysis</subject><subject>Resistance Training</subject><subject>Sports Medicine</subject><subject>Strength training</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><subject>Weight control</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kUuLFTEQhYMozjj6A9xIEEQ3rXmn250M4wMG3Oi6ya2uaMbu5JqkF9dfb5p7nQFBV1UhX52cyiHkKWevOWP2TWFMCd4xzjpujez0PXLOlRw6I4W9f9vz4Yw8KuWGMdYL3j8kZ4Jzw4XR5yRceY9QafI0YwmlughIa3YhhviNTmveyndc0hTcfGgETZFCyLDOrm53cKjpR4hY3lJHs4tTWsIvnCikWHOa59bW3GYfkwfezQWfnOoF-fr-6svlx-7684dPl--uO1BS1o5PwnkAvWMgcWeF92YCK0AgKublYPTklUJvYbAOdx5c29VrDcYa5QcmL8jLo-4-p58rljouoQDOs4uY1jL2lg-mt0w38tV_Sc6k6tmgpWzo87_Qm7Tm2PbY9LRWlvcN4kcIciolox_3OSwuH5rSuAU2HgMb2XZugY2bh2cn4XW34HQ78SehBrw4Aa6Am337YQjljlNiaCZN48SRK_stMsx3Dv_9-m8SGK8Y</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Cheema, Birinder Singh Bobby</creator><creator>Abas, Haifa</creator><creator>Smith, Benjamin C. F.</creator><creator>O’Sullivan, Anthony J.</creator><creator>Chan, Maria</creator><creator>Patwardhan, Aditi</creator><creator>Kelly, John</creator><creator>Gillin, Adrian</creator><creator>Pang, Glen</creator><creator>Lloyd, Brad</creator><creator>Berger, Klaus</creator><creator>Baune, Bernhard T.</creator><creator>Fiatarone Singh, Maria A.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7T5</scope><scope>7TS</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial</title><author>Cheema, Birinder Singh Bobby ; Abas, Haifa ; Smith, Benjamin C. F. ; O’Sullivan, Anthony J. ; Chan, Maria ; Patwardhan, Aditi ; Kelly, John ; Gillin, Adrian ; Pang, Glen ; Lloyd, Brad ; Berger, Klaus ; Baune, Bernhard T. ; Fiatarone Singh, Maria A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose tissue</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body composition</topic><topic>Chronic illnesses</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Exercise - physiology</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nutrition</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Quality of life</topic><topic>Renal Dialysis</topic><topic>Resistance Training</topic><topic>Sports Medicine</topic><topic>Strength training</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheema, Birinder Singh Bobby</creatorcontrib><creatorcontrib>Abas, Haifa</creatorcontrib><creatorcontrib>Smith, Benjamin C. F.</creatorcontrib><creatorcontrib>O’Sullivan, Anthony J.</creatorcontrib><creatorcontrib>Chan, Maria</creatorcontrib><creatorcontrib>Patwardhan, Aditi</creatorcontrib><creatorcontrib>Kelly, John</creatorcontrib><creatorcontrib>Gillin, Adrian</creatorcontrib><creatorcontrib>Pang, Glen</creatorcontrib><creatorcontrib>Lloyd, Brad</creatorcontrib><creatorcontrib>Berger, Klaus</creatorcontrib><creatorcontrib>Baune, Bernhard T.</creatorcontrib><creatorcontrib>Fiatarone Singh, Maria A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Immunology Abstracts</collection><collection>Physical Education Index</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheema, Birinder Singh Bobby</au><au>Abas, Haifa</au><au>Smith, Benjamin C. F.</au><au>O’Sullivan, Anthony J.</au><au>Chan, Maria</au><au>Patwardhan, Aditi</au><au>Kelly, John</au><au>Gillin, Adrian</au><au>Pang, Glen</au><au>Lloyd, Brad</au><au>Berger, Klaus</au><au>Baune, Bernhard T.</au><au>Fiatarone Singh, Maria A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>111</volume><issue>7</issue><spage>1437</spage><epage>1445</epage><pages>1437-1445</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>The purpose of this study was to evaluate the effect of a 12-week intradialytic progressive resistance training (PRT) regimen on circulating pro- and anti-inflammatory cytokines. Forty-nine patients (62.6 ± 14.2 years) were recruited from the outpatient hemodialysis unit of the St. George Public Hospital, Sydney, Australia. Patients were randomized to: PRT + usual care (
n
= 24) or usual care control (
n
= 25). The PRT group performed two sets of 10 exercises at high intensity using free-weights, 3 times per week for 12 weeks during dialysis, while the control group did not exercise. Tumor necrosis factor-alpha, interleukin-1b, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, and interleukin-12 were measured in serum before and after the intervention period. Muscle cross-sectional area (CSA), intramuscular lipid, intermuscular adipose tissue, and subcutaneous and total thigh fat, evaluated via computed tomography of the non-dominant mid-thigh, were also collected at both time points. All cytokines were significantly elevated in the total cohort at baseline compared with normative data. There were no cytokine changes over time or between groups (
p
> 0.05). In secondary analyses pooling the groups, changes in logIL-6 and IL-8 were inversely related to changes subcutaneous thigh fat (
p
< 0.05) while changes in logIL-6 were also inversely related to changes in thigh muscle CSA, and total thigh fat (
p
< 0.03). These data suggest that 12 weeks of intradialytic progressive resistance training does not improve circulating pro- and anti-inflammatory markers. Further research is required to elucidate the implications and mechanisms of the relationships between IL-6 and IL-8 and body composition in ESRD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21161265</pmid><doi>10.1007/s00421-010-1763-5</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2011-07, Vol.111 (7), p.1437-1445 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_871968705 |
| source | Springer Link |
| subjects | Adipose tissue Aged Algorithms Biological and medical sciences Biomedical and Life Sciences Biomedicine Body composition Chronic illnesses Clinical trials Cytokines Cytokines - blood Cytokines - metabolism Exercise - physiology Exercise Therapy Female Fundamental and applied biological sciences. Psychology Hemodialysis Hospitals Human Physiology Humans Kidney diseases Kidney Failure, Chronic - blood Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Medicine Middle Aged Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Nutrition Occupational Medicine/Industrial Medicine Original Article Quality of life Renal Dialysis Resistance Training Sports Medicine Strength training Treatment Outcome Tumor necrosis factor-TNF Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Weight control |
| title | Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T20%3A33%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20resistance%20training%20during%20hemodialysis%20on%20circulating%20cytokines:%20a%20randomized%20controlled%20trial&rft.jtitle=European%20journal%20of%20applied%20physiology&rft.au=Cheema,%20Birinder%20Singh%20Bobby&rft.date=2011-07-01&rft.volume=111&rft.issue=7&rft.spage=1437&rft.epage=1445&rft.pages=1437-1445&rft.issn=1439-6319&rft.eissn=1439-6327&rft_id=info:doi/10.1007/s00421-010-1763-5&rft_dat=%3Cproquest_cross%3E1034809533%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c433t-1d2afcc5b0c3eb72ff6dc72c2ee40f3965df44ef7c97aebfca327f55c6764f903%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=871554718&rft_id=info:pmid/21161265&rfr_iscdi=true |