The association between past Chlamydia pneumoniae infection and markers of chronic inflammation in obese women

It has been widely accepted that obesity is associated with chronic, low-grade inflammation that affects the adipose tissue as well as the entire system. The aim of this study was to assess whether past Chlamydia pneumoniae infection influences obesity phenotypes and serum levels of low-grade inflam...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2008-06, Vol.27 (6), p.415-421
Main Authors: Koziołek, M., Krzyżanowska-Świniarska, B., Mączyńska, I., Miazgowski, T., Giedrys-Kalemba, S.
Format: Article
Language:English
Subjects:
Adipose tissue
Biological and medical sciences
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood Glucose - metabolism
Body fat
Body Mass Index
Body Weight - physiology
C-Reactive Protein - metabolism
Chlamydia Infections - complications
Chlamydia Infections - immunology
Chlamydophila pneumoniae
Chlamydophila pneumoniae - immunology
Chronic Disease
Female
Humans
Infectious diseases
Inflammation - complications
Insulin
Insulin Resistance
Internal Medicine
Medical Microbiology
Medical sciences
Metabolic diseases
Obesity
Obesity - blood
Obesity - microbiology
Obesity - physiopathology
Regression analysis
Sexually transmitted diseases
STD
Tumor necrosis factor-TNF
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Summary:It has been widely accepted that obesity is associated with chronic, low-grade inflammation that affects the adipose tissue as well as the entire system. The aim of this study was to assess whether past Chlamydia pneumoniae infection influences obesity phenotypes and serum levels of low-grade inflammation markers in obese, healthy premenopausal women. The study was performed on 48 obese and 42 normal-weight women, aged 31.2 ± 7.2 years. Serum levels of C-reactive protein (CRP), tumor necrosis factor α (TNFα) and its soluble receptor R2 (sTNF-R2), and interleukin 6 (IL-6) were measured. Body composition was assessed by bioimpendance. Insulin sensitivity was assessed by quantitative insulin sensitivity check index (QUICKI). The seroprevalence of C. pneumoniae infection was 69.1% and was similar in obese and normal-weight women (75.2% and 61.9%, respectively; P  = 0.18). Obese women had higher CRP than healthy controls ( P  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-007-0446-6