Glial solute carrier transporters in drosophila and mice

Glia regulate brain physiology primarily by regulating the movement and concentration of substances in the extracellular fluid. Therefore, one approach to understanding the role of glia in brain physiology is to study what happens when glial transporters are removed or modified. The largest and most...

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Bibliographic Details
Published in:Glia 2011-09, Vol.59 (9), p.1351-1363
Main Author: Featherstone, David E.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain Chemistry - genetics
Brain Chemistry - physiology
Carrier Proteins - genetics
Carrier Proteins - metabolism
Drosophila
Drosophila - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Fruit flies
Glia
Insects
Mice
Models, Genetic
mouse
Neuroglia - metabolism
Physiology
Proteins
SLCproteins
solute carrier proteins
Solutes
Transmembrane proteins
transporter
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Summary:Glia regulate brain physiology primarily by regulating the movement and concentration of substances in the extracellular fluid. Therefore, one approach to understanding the role of glia in brain physiology is to study what happens when glial transporters are removed or modified. The largest and most highly conserved class of transporter is solute carrier (SLC) proteins. SLC proteins are highly expressed in brain, and many are found in glia. The function of many SLC proteins in the brain—particularly in glia—is very poorly understood. SLC proteins can be relatively easily knocked out or modified in genetic model organisms to better understand glial function. Drosophila are popular genetic model organisms that offer a nice balance between genetic malleability and brain complexity. They are ideal for such an endeavor. This article lists and discusses SLC transporter family members that are expressed in both mouse and Drosophila glia, in an effort to provide a foundation for studies of glial SLC transporters using Drosophila as a model. © 2010 Wiley‐Liss, Inc.
ISSN:0894-1491
1098-1136
1098-1136
DOI:10.1002/glia.21085