Differentiation, phenotype, and function of interleukin-17–producing human Vγ9Vδ2 T cells

In healthy adults, the major peripheral blood γδ T-cell subset expresses the Vγ9Vδ2 TCR and displays pleiotropic features. Here we report that coculture of naive Vγ9Vδ2 T cells with phosphoantigens and a cocktail of cytokines (IL-1-β, TGF-β, IL-6, and IL-23), leads to selective expression of the tra...

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Bibliographic Details
Published in:Blood 2011-07, Vol.118 (1), p.129-138
Main Authors: Caccamo, Nadia, La Mendola, Carmela, Orlando, Valentina, Meraviglia, Serena, Todaro, Matilde, Stassi, Giorgio, Sireci, Guido, Fournié, Jean Jacques, Dieli, Francesco
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, Bacterial - immunology
beta-Defensins - immunology
beta-Defensins - metabolism
Biological and medical sciences
Cell Differentiation - immunology
Cell Lineage - immunology
Cells, Cultured
Child
Child, Preschool
Coculture Techniques
Female
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Interleukin-17 - immunology
Interleukin-17 - metabolism
Interleukin-8 - immunology
Interleukin-8 - metabolism
Male
Medical sciences
Meningitis, Bacterial - immunology
Meningitis, Bacterial - physiopathology
Neutrophils - cytology
Neutrophils - immunology
Phagocytosis - immunology
Receptors, Antigen, T-Cell, gamma-delta - immunology
Receptors, Antigen, T-Cell, gamma-delta - metabolism
Th17 Cells - immunology
Th17 Cells - metabolism
Th17 Cells - microbiology
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