Efficacy of conventional and extended intra-mammary treatment of persistent sub-clinical mastitis with cefquinome in lactating dairy cows

• Published in: Tropical animal health and production 2011-08, Vol.43 (6), p.1203-1210
• Main Authors: Kasravi, Reza, Bolourchi, Mahmoud, Farzaneh, Nima, Seifi, Hesam A., Barin, Abbas, Hovareshti, Parviz, Gharagozlou, Faramarz
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Asymptomatic Infections - therapy; Biomedical and Life Sciences; Cattle; Cell Count; Cephalosporins - administration & dosage; Cephalosporins - therapeutic use; Dairy cattle; Enterobacteriaceae - isolation & purification; Enterobacteriaceae Infections - drug therapy; Enterobacteriaceae Infections - veterinary; Female; Injections, Intradermal - veterinary; Iran; Life Sciences; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - microbiology; Mastitis, Bovine - drug therapy; Mastitis, Bovine - microbiology; Milk production; Original Research; Staphylococcal Infections - drug therapy; Staphylococcal Infections - veterinary; Staphylococcus - isolation & purification; Streptococcal Infections - drug therapy; Streptococcal Infections - veterinary; Streptococcus - isolation & purification; Streptococcus agalactiae; Time Factors; Veterinary Medicine/Veterinary Science; Zoology
• ISSN: 0049-4747; 1573-7438
• DOI: 10.1007/s11250-011-9826-0

The objectives of the present study were to evaluate the efficacy of intra-mammary-administered cefquinome for the treatment of sub-clinical mastitis in lactating dairy cows and to determine if extended therapy would enhance treatment efficacy. Seventy-three Holstein dairy cows from a single farm with 150 infected quarters were enrolled in the study. Infected cows were allocated randomly to one of three treatment regimens: (1) conventional (standard) regimen: 75 mg of cefquinome administered three times at 16-h intervals (25 infected cows, 52 intra-mammary infections (IMI)), (2) extended regimen: 75 mg of cefquinome administered six times at 16-h intervals (26 infected cows, 58 IMI) and (3) negative untreated control group (22 cows, 40 IMI). Most IMI were caused by coagulase-negative staphylococci, streptococci other than Streptococcus agalactiae and coliforms. The overall bacteriological cure (BC) rates for sub-clinical IMI were 84.61%, 91.37% and 20% for the conventional, extended and the control groups, respectively, indicating a higher BC rate for the treated groups than the control group ( P