Linked Metabolites: A tool for the construction of directed metabolic graphs

Abstract Metabolic pathway diagrams provide a wealth of information on how reactions combine to perform biological functions. While pathway diagrams are arranged in a way that allows a specific area of metabolism to be visualised, the inherent complexity of each pathway makes it difficult to identif...

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Bibliographic Details
Published in:Computers in biology and medicine 2010-03, Vol.40 (3), p.340-349
Main Authors: Easton, John M, Harris, Lisa M, Viant, Mark R, Peet, Andrew C, Arvanitis, Theodoros N
Format: Article
Language:English
Subjects:
Algorithms
All simple paths search
Computer Graphics
Database Management Systems
Directed graphs
Humans
Internal Medicine
KEGG
Metabolic pathways
Metabolism
Metabolomics
Other
User-Computer Interface
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Summary:Abstract Metabolic pathway diagrams provide a wealth of information on how reactions combine to perform biological functions. While pathway diagrams are arranged in a way that allows a specific area of metabolism to be visualised, the inherent complexity of each pathway makes it difficult to identify the sets of reactions linking groups of compounds; a common task for researchers attempting to explain observed correlations or looking for further compounds of potential interest to use in validation work. Here we introduce Linked Metabolites, a tool that identifies sets of reactions linking groups of compounds in the context of the KEGG pathway diagrams.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2010.01.005