Effects of perinatal exposure to bisphenol A on the behavior of offspring in F344 rats

The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent mann...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2003-09, Vol.14 (3), p.99-108
Main Authors: Negishi, Takayuki, Kawasaki, Katsuyoshi, Takatori, Atsushi, Ishii, Yoshiyuki, Kyuwa, Shigeru, Kuroda, Yoichiro, Yoshikawa, Yasuhiro
Format: Article
Language:English
Subjects:
Active avoidance test
Bisphenol A
Development
Open-field behavior
Rat
Spontaneous activity
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Summary:The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent manner, which continued after weaning. Spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring. At 4 weeks of age, male offspring exposed to BPA at 40 and 400 mg/kg per day performed avoidance responses significantly higher in the shuttlebox avoidance test. At 8 weeks of age, however, male offspring only at 4 mg/kg per day showed significantly lower responses. In the open-field behavior test at 8 weeks of age, male offspring exposed to BPA only at 4 mg/kg per day showed a higher percent of grooming than the control male offspring. In conclusion, perinatal exposure to BPA caused the behavioral alterations in the offspring.
ISSN:1382-6689
1872-7077
DOI:10.1016/S1382-6689(03)00044-9