Pharmacokinetics of thiamine in female Baltic salmon ( Salmo salar L.) broodfish

A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and far...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2005, Vol.19 (1), p.139-152
Main Authors: Koski, Perttu, Bäckman, Christina, Pelkonen, Olavi
Format: Article
Language:English
Subjects:
Baltic
M74 syndrome
Pharmacokinetics
Salmo salar
Salmon
Thiamine
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Summary:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon females preparing for spawning. The total thiamine concentrations in the eggs and white muscle of feral females were only half of those in the farmed fish after injection. The relative inefficiency of the incorporation of thiamine into the eggs in feral Baltic salmon may be a predisposition factor for M74 syndrome. The relative bioavailability of intraperitoneally-injected thiamine hydrochloride was shown to be ca. 94% of that administered intra-aortically. A far lower intraperitoneal dose (ca. 20 mg kg −1 fish) than currently used was shown to elevate the total thiamine concentration in the eggs above the critical threshold of M74 syndrome.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2004.06.001