Fourteen‐year‐old girl with recurrent luteal‐phase‐dependent episodes of high fever

• Published in: The journal of obstetrics and gynaecology research 2011-08, Vol.37 (8), p.1166-1168
• Main Authors: Yamasaki, Hideki, Oki, Toshimichi, Iwamoto, Ichiro, Douchi, Tsutomu
• Format: Article
• Language: English
• Subjects: Adolescent; Cytokines - blood; Female; Fever - blood; Fever - etiology; Fever - prevention & control; Gonadotropin-Releasing Hormone - agonists; Humans; inflammatory cytokines; luteal phase; Luteal Phase - blood; Ovulation Inhibition; recurrent fever attack; Secondary Prevention; Severity of Illness Index
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/j.1447-0756.2010.01495.x

Recurrent episodes of high fever during the luteal phase are exceedingly rare. A 14‐year‐old girl with a 1‐year history of recurrent febrile episodes associated with the menstrual cycle was referred to our department. Febrile episode (39–41°C) occurred for 10 to 12 days concomitantly with the luteal phase of each ovulatory cycle. To suppress the ovulatory cycle, gonadotropin releasing hormone agonist was administered for 5 months, and then febrile attack disappeared (34.5–36.2°C). Before and during gonadotropin releasing hormone agonist therapy, serum levels of inflammatory cytokines (interleukin [IL]‐1β, IL‐2, IL‐6, IL‐8, IL‐10, and tumor necrosis factor‐α) were unchanged and all of these were within the normal ranges. In our case, luteal‐phase‐dependent febrile episodes may not be attributable to the intervention of inflammatory cytokines as major fever mediators.