Isoxazol-5(4H)one Derivatives as PTP1B Inhibitors Showing an Anti-Obesity Effect

In developing inhibitors of therapeutic target enzymes, significant time and effort are committed to the preparation of large numbers of compounds. In an effort to develop a potent inhibitor of protein tyrosine phosphatase (PTP) 1B as an anti‐obesity and/or anti‐diabetic agent, we constructed an iso...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2011-08, Vol.6 (8), p.2073-2079
Main Authors: Kafle, Bhooshan, Aher, Nilkanth G., Khadka, Deegendra, Park, Hwangseo, Cho, Hyeongjin
Format: Article
Language:English
Subjects:
Animals
Anti-Obesity Agents - chemistry
Anti-Obesity Agents - pharmacology
Chemistry
diabetes
enzymes
heterocycles
inhibitors
Isoxazoles - chemistry
Isoxazoles - pharmacology
Male
Mice
Mice, Inbred C57BL
Obesity - drug therapy
Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism
PTP1B
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