Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance

A quartz crystal microbalance （QCM） is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0-11 MPa and at temperatures of 35 °C,40 °C and 45 °C.The experimental results indicated that gaseous CO2 could be absorbed poorly into paclitaxel.The swelling...

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Bibliographic Details
Published in:Chinese journal of chemical engineering 2011-04, Vol.19 (2), p.227-231
Main Author: 焦真 陈志明 吴有庭 马少玲
Format: Article
Language:English
Subjects:
Carbon dioxide
Chemical engineering
Dissolution
Microorganisms
paclitaxel
phase behavior
quartz crystal microbalance
Quartz crystals
Solubility
Solvents
Swelling
二氧化碳体系
二氧化碳气体
压力范围
定碳
溶解度
石英晶体微天平
紫杉醇
超临界二氧化碳
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Summary:A quartz crystal microbalance （QCM） is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0-11 MPa and at temperatures of 35 °C,40 °C and 45 °C.The experimental results indicated that gaseous CO2 could be absorbed poorly into paclitaxel.The swelling of paclitaxel film in CO2 was observed before paclitaxel dissolved into supercritical carbon dioxide （ScCO2） with the increase of pressure.It was found that ScCO2 was not a good solvent for paclitaxel.The mole fraction of paclitaxel in ScCO2 was in the range of （4.5×10-9）-（7.8×10-9） under all our experimental conditions.Therefore,a much higher pressure than the CO2 supercritical point and/or a cosolvent must be used in any processes wherever paclitaxel dissolution in ScCO2 is required.
ISSN:1004-9541
2210-321X
DOI:10.1016/S1004-9541(11)60159-6