Diet-Induced Obesity Attenuates Fasting-Induced Hyperphagia

Obesity impairs arcuate (ARC) neuropeptide Y (NPY)/agouti‐releated peptide (AgRP) neuronal function and renders these homeostatic neurones unresponsive to the orexigenic hormone ghrelin. In the present study, we investigated the effect of diet‐induced obesity (DIO) on feeding behaviour, ARC neuronal...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2011-07, Vol.23 (7), p.620-626
Main Authors: Briggs, D. I., Lemus, M. B., Kua, E., Andrews, Z. B.
Format: Article
Language:English
Subjects:
Agouti-Related Protein - genetics
Agouti-Related Protein - metabolism
AgRP
Animals
Appetite
arcuate nucleus
Arcuate Nucleus of Hypothalamus - metabolism
Biological and medical sciences
Diet - adverse effects
Diet, Atherogenic
Down-Regulation
energy balance
Fasting - physiology
Feeding behavior
Feeding Behavior - physiology
Fundamental and applied biological sciences. Psychology
Gene expression
ghrelin
Hormones
Hyperphagia
Hyperphagia - complications
Hyperphagia - etiology
Hyperphagia - genetics
Hyperphagia - metabolism
Hypothalamus
Male
Medical sciences
Metabolic diseases
Mice
Mice, Inbred C57BL
Mice, Obese
Neuropeptide Y
Neuropeptide Y - genetics
Neuropeptide Y - metabolism
NPY
Obesity
Obesity - complications
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
refeeding
Reinforcement
Vertebrates: endocrinology
Citations: Items that cite this one
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Summary:Obesity impairs arcuate (ARC) neuropeptide Y (NPY)/agouti‐releated peptide (AgRP) neuronal function and renders these homeostatic neurones unresponsive to the orexigenic hormone ghrelin. In the present study, we investigated the effect of diet‐induced obesity (DIO) on feeding behaviour, ARC neuronal activation and mRNA expression following another orexigenic stimulus, an overnight fast. We show that 9 weeks of high‐fat feeding attenuates fasting‐induced hyperphagia by suppressing ARC neuronal activation and hypothalamic NPY/AgRP mRNA expression. Thus, the lack of appropriate feeding responses in DIO mice to a fast is caused by failure ARC neurones to recognise and/or respond to orexigenic cues. We propose that fasting‐induced hyperphagia is regulated not by homeostatic control of appetite in DIO mice, but rather by changes in the reward circuitry.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2011.02148.x