Photo-tunable protein release from biodegradable nanoparticles composed of cinnamic acid derivatives

A novel functional biodegradable copolymer was prepared by grafting dithiothreitiol (DTT) into poly(3,4-dihydroxycinnamic acid)- co-poly(4-hydroxycinnamic acid) (PCA) by the Michael addition. The PCA- graft-DTT (PCA-DTT) nanoparticles were self-assembled by mixing a DMSO solution of PCA-DTT copolyme...

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Bibliographic Details
Published in:Journal of controlled release 2011-01, Vol.149 (2), p.182-189
Main Authors: Shi, Dongjian, Matsusaki, Michiya, Akashi, Mitsuru
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - radiation effects
biodegradability
Biodegradable nanoparticles
Biological and medical sciences
bovine serum albumin
Cinnamates - chemistry
Cinnamates - radiation effects
cinnamic acid
composite polymers
Cross-Linking Reagents - chemistry
Cross-Linking Reagents - radiation effects
crosslinking
dimethyl sulfoxide
Dithiothreitol - chemistry
Dithiothreitol - radiation effects
drug carriers
Drug Carriers - chemistry
Drug Carriers - radiation effects
Drug controlled release
General pharmacology
Medical sciences
Microscopy, Electron, Scanning
mixing
Molecular Structure
nanoparticles
Nanoparticles - chemistry
Nanoparticles - radiation effects
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Photo-crosslinking
Polyesters - chemistry
Polyesters - radiation effects
Serum Albumin, Bovine - chemistry
shrinkage
Size change
Solubility
Sulfhydryl Compounds - chemistry
Sulfhydryl Compounds - radiation effects
Surface Properties
ultraviolet radiation
Ultraviolet Rays
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