Influence of a magnesium-fluoride coating of magnesium-based implants (MgCa0.8) on degradation in a rabbit model

MgCa0.8 cylinders (2.5 × 25 mm2) were coated with a magnesium‐fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro‐computed tomography revealed a new bone f...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2010-06, Vol.93A (4), p.1609-1619
Main Authors: Thomann, Martina, Krause, Christian, Angrisani, Nina, Bormann, Dirk, Hassel, Thomas, Windhagen, Henning, Meyer-Lindenberg, Andrea
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
biodegradation
Biological and medical sciences
Bone Substitutes - chemistry
Calcium - chemistry
Female
fluoride layer
Fluorides - chemistry
magnesium
Magnesium - chemistry
Magnesium Compounds - chemistry
Medical sciences
Microscopy, Electron, Scanning - methods
Orthopedic surgery
Osseointegration
Prostheses and Implants
Rabbits
Stress, Mechanical
surface treatment
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tibia - pathology
Time Factors
X-Ray Microtomography - methods
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Summary:MgCa0.8 cylinders (2.5 × 25 mm2) were coated with a magnesium‐fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro‐computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX‐analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res 2010
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32639