Host inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response

Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by a positive RNA strand arterivirus. PRRS virus (PRRSV) interacts primarily with lung macrophages. Little is known how the virus subverts the innate immune response to initiate its replication in alveolar macrophag...

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Bibliographic Details
Published in:Immunogenetics (New York) 2011-07, Vol.63 (7), p.437-448
Main Authors: Ait-Ali, Tahar, Wilson, Alison D., Carré, Wilfrid, Westcott, David G., Frossard, Jean-Pierre, Mellencamp, Marnie A., Mouzaki, Daphne, Matika, Oswald, Waddington, David, Drew, Trevor W., Bishop, Stephen C., Archibald, Alan L.
Format: Article
Language:English
Subjects:
Allergology
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Gene Expression Regulation
Gene Function
Hogs
Host-Pathogen Interactions - genetics
Human Genetics
Immune response
Immunity, Innate - genetics
Immunology
Infections
Infectious diseases
Interferon
Interferon Type I - genetics
Macrophages, Alveolar - immunology
Macrophages, Alveolar - virology
Original Paper
Porcine Reproductive and Respiratory Syndrome - genetics
Porcine Reproductive and Respiratory Syndrome - immunology
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - physiology
Swine
Transcription, Genetic
Viral infections
Virus Replication
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Summary:Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by a positive RNA strand arterivirus. PRRS virus (PRRSV) interacts primarily with lung macrophages. Little is known how the virus subverts the innate immune response to initiate its replication in alveolar macrophages. Large-scale transcriptional responses of macrophages with different levels of susceptibility to PRRSV infection were compared over 30 h of infection. This study demonstrates a rapid and intense host transcriptional remodelling during the early phase of the replication of the virus which correlates with transient repression of type-I interferon transcript as early as 8 h post-infection. These results support the suggestion from previous studies that host innate immune response inhibits replication of European porcine reproductive and respiratory syndrome virus in macrophages by altering differential regulation of type-I interferon transcriptional response.
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-011-0518-8