Detection of the t(11;14)(q13;q32) without CCND1/IGH fusion in a case of acute myeloid leukemia

Abstract The t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma. It has been found less frequently in other lymphoproliferative disorders, such as B-prolymphocytic leukemia, plasma cell leukemia, chronic lymphocytic leukemia, and multiple myeloma. Here, we describe a patient with acute myeloid...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2009-12, Vol.195 (2), p.164-167
Main Authors: Tarsitano, Marina, Palmieri, Salvatore, Ferrara, Felicetto, Riccardi, Cira, Cavaliere, Maria Luigia, Vicari, Laura
Format: Article
Language:English
Subjects:
Bone Marrow - pathology
Cyclin D1 - genetics
Female
Hematology, Oncology and Palliative Medicine
Humans
Immunoglobulin Heavy Chains - genetics
Karyotyping
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Medical Education
Middle Aged
Translocation, Genetic
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Summary:Abstract The t(11;14)(q13;q32) is a hallmark of mantle cell lymphoma. It has been found less frequently in other lymphoproliferative disorders, such as B-prolymphocytic leukemia, plasma cell leukemia, chronic lymphocytic leukemia, and multiple myeloma. Here, we describe a patient with acute myeloid leukemia (AML), categorized as M5b according to French–American–British classification, in which conventional cytogenetic analysis revealed a karyotype with t(11;14)(q13;q32). Fluorescence in situ hybridization analyses demonstrated no rearrangement of the immunoglobulin heavy-chain ( IGH ) (14q32) locus as well as of the cyclin D1 ( CCND1 ) gene, suggesting that this is not the typical t(11;14) resulting from the CCND1/IGH fusion. The changes in the 11q13 region have been described in both myeloid and lymphoid neoplasm with different chromosomes serving as donors in translocation, but to the best of our knowledge, never with the chromosome 14.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2009.08.013