In vitro evaluation of samarium (III) oxide as a bone substituting material

The biocompatibility of natural samarium (III) oxide, which has previously been used for treatment in bone‐related diseases was determined as a first step in its evaluation as a bone implant material. Assessment for 28 days using osteoblast‐like cells revealed no indications of cytotoxicity. The cel...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2010-07, Vol.94A (1), p.130-136
Main Authors: Herath, H. M. T. U., Di Silvio, L., Evans, J. R. G.
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - metabolism
biocompatibility
Biocompatible Materials - chemistry
Biological and medical sciences
Bone Substitutes - chemistry
cell culture
Cell Differentiation
Cell Line
Cell Membrane - metabolism
Cell Proliferation
Cells, Cultured
cytotoxicity
Humans
lanthanides
Materials Testing
Medical sciences
Orthopedic surgery
Osteoblasts - cytology
Osteoblasts - physiology
Oxides - chemistry
Phenotype
samarium (III) oxide
Samarium - chemistry
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
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Summary:The biocompatibility of natural samarium (III) oxide, which has previously been used for treatment in bone‐related diseases was determined as a first step in its evaluation as a bone implant material. Assessment for 28 days using osteoblast‐like cells revealed no indications of cytotoxicity. The cells adhered and proliferated on the surface. Furthermore, the differentiation and mineralization were observed, indicating a normal biological response of the cells on the samarium (III) oxide surface. The in vitro, short term biocompatibility assessment of this oxide has indicated its biosafety with no damaging toxic effects on the cells and biofunctionality; with an appropriate cell response for a bone‐contacting material. Hence, samarium (III) oxide deserves recognition in the field of biomaterials for its excellent in vitro performance and demonstrates that the class of potential bioceramics may be larger than previously thought. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32667