Quantitative Computed Tomography Analysis, Airflow Obstruction, and Lung Cancer in the Pittsburgh Lung Screening Study

To study the relationship between emphysema, airflow obstruction, and lung cancer in a high-risk population, we performed quantitative analysis of screening computed tomography (CT) scans. Subjects completed questionnaires, spirometry, and low-dose helical chest CT. Analyses compared cases and contr...

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Bibliographic Details
Published in:Journal of thoracic oncology 2011-07, Vol.6 (7), p.1200-1205
Main Authors: Wilson, David O., Leader, Joseph K., Fuhrman, Carl R., Reilly, John J., Sciurba, Frank C., Weissfeld, Joel L.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Airflow obstruction
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - pathology
Case-Control Studies
Cohort Studies
Early Detection of Cancer
Emphysema
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Lung cancer risk
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Male
Middle Aged
Prognosis
Pulmonary Emphysema - diagnostic imaging
Pulmonary Emphysema - pathology
Respiration
Risk Factors
Smoking
Tomography, X-Ray Computed
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Summary:To study the relationship between emphysema, airflow obstruction, and lung cancer in a high-risk population, we performed quantitative analysis of screening computed tomography (CT) scans. Subjects completed questionnaires, spirometry, and low-dose helical chest CT. Analyses compared cases and controls according to automated quantitative analysis of lung parenchyma and airways measures. Our case-control study of 117 matched pairs of lung cancer cases and controls did not reveal any airway or lung parenchymal findings on quantitative analysis of screening CT scans that were associated with increased lung cancer risk. Airway measures including wall area %, lumen perimeter, lumen area and average wall Hounsfield unit, and parenchymal measures including lung fraction less than −910 Hounsfield units were not statistically different between cases and controls. The relationship between visual assessment of emphysema and increased lung cancer risk could not be verified by quantitative analysis of low-dose screening CT scans in a high-risk tobacco exposed population.
ISSN:1556-0864
1556-1380
DOI:10.1097/JTO.0b013e318219aa93