Evaluation of basal cell carcinoma microcirculation through orthogonal polarization technique

Basal cell carcinomas are the most common cutaneous neoplasias. They rarely metastasize, but can cause clinically significant local destruction and disfigurement if neglected or inadequately treated. The spectral imaging technique, a recently developed method of orthogonal light polarization, allows...

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Bibliographic Details
Published in:Archives of Dermatological Research 2011-09, Vol.303 (7), p.475-479
Main Authors: Semenovitch, Ivan, Sicuro, Fernando, Lupi, Omar, Bouskela, Eliete
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Capillaries - pathology
Carcinoma, Basal Cell - blood supply
Carcinoma, Basal Cell - diagnosis
Carcinoma, Basal Cell - pathology
Dermatology
Erythrocytes - metabolism
Erythrocytes - pathology
Female
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Microcirculation
Microscopy, Polarization - instrumentation
Microscopy, Polarization - methods
Middle Aged
Neovascularization, Pathologic
Original Paper
Skin - blood supply
Skin Neoplasms - blood supply
Skin Neoplasms - diagnosis
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Basal cell carcinomas are the most common cutaneous neoplasias. They rarely metastasize, but can cause clinically significant local destruction and disfigurement if neglected or inadequately treated. The spectral imaging technique, a recently developed method of orthogonal light polarization, allows in vivo transcutaneous evaluation of tumor microcirculation. The objective of this work was to compare tumor and normal skin microcirculation in patients using the orthogonal polarization (OPS) technique. Forty histologically confirmed basal cell carcinomas of 36 patients were evaluated in order to accomplish our objective. Compared to control skin, basal cell carcinomas had significantly greater capillary diameters (10.6 ± 2.6 and 18.5 ± 6.2 μm, respectively), capillary density (25.0 ± 10.4 and 50.3 ± 16.9 cm/cm 2 , respectively) and red blood cell velocities (0.06 ± 0.03 and 0.11 ± 0.07 mm/s). Our results have demonstrated significant microcirculatory alterations in skin tumors using the OPS technique that allows its transcutaneous evaluation in vivo, in the absence of anesthesia and invasive surgical procedures. This technique could be a promising tool for researchers studying diseases in which angiogenesis plays a major role.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-011-1151-y