Biophysical model estimation of neurovascular parameters in a rat model of healthy aging

Neuronal, vascular and metabolic factors result in a deterioration of the cerebral hemodynamic response with age. The interpretation of neuroimaging studies in the context of aging is rendered difficult due to the challenge in untangling the composite effect of these modifications. In this work we i...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2011-08, Vol.57 (4), p.1480-1491
Main Authors: Dubeau, S., Desjardins, M., Pouliot, P., Beaumont, E., Gaudreau, P., Ferland, G., Lesage, F.
Format: Article
Language:English
Subjects:
Age
Aging
Aging - physiology
Algorithms
Anatomy & physiology
Animals
Bayesian statistical methods
Biomechanics
Biophysical models
Biophysical Phenomena
Brain - blood supply
Cerebrovascular Circulation - physiology
Female
Hemodynamics - physiology
Intrinsic optical imaging
LOU/c rat
Male
Medical imaging
Models, Animal
Rats
Smooth muscle
Studies
Tomography
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Summary:Neuronal, vascular and metabolic factors result in a deterioration of the cerebral hemodynamic response with age. The interpretation of neuroimaging studies in the context of aging is rendered difficult due to the challenge in untangling the composite effect of these modifications. In this work we integrate multimodal optical imaging in biophysical models to investigate vascular and metabolic changes occurring in aging. Multispectral intrinsic optical imaging of an animal model of healthy aging, the LOU/c rat, is used in combination with somatosensory stimulation to study the modifications of the hemodynamic response with increasing age. Results are fitted with three macroscopic biophysical models to extract parameters, providing a phenomenological description of vascular and metabolic changes. Our results show that 1) biophysical parameters are estimable from multimodal data and 2) parameter estimates in this population change with aging. ► Biophysical parameters estimated from multimodal data with aging in rat model. ► Three biophysical models compared. ► Parameters found to be estimable from experimental data. ► Baseline blood flow and CMRO2 decrease with age. ► Vascular compliance parameter decrease with age.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2011.04.030