Prevalence and Clinical Implications of Positive Serum Anti-Microsomal Antibodies in Symptomatic Patients with Ileal Pouches

Background and aim Autoimmune disorders (AID) have been shown to be associated with chronic antibiotic-refractory pouchitis (CARP). The role of anti-microsomal antibodies in ileal pouch disorders has not been investigated. The aims of the study were to investigate the prevalence of positive anti-mic...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2011-09, Vol.15 (9), p.1577-1582
Main Authors: Navaneethan, Udayakumar, Venkatesh, Preethi G. K., Manilich, Elena, Kiran, Ravi P., Remzi, Feza H., Shen, Bo
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Antibiotics
Antibodies
Autoantibodies - blood
Autoimmune diseases
Autoimmune Diseases - blood
Autoimmune Diseases - complications
Budesonide - therapeutic use
Cholangitis
Cholangitis, Sclerosing - complications
Clinical medicine
Crohn Disease - complications
Drug Resistance, Bacterial
Endoscopy
Female
Gastroenterology
Hashimoto Disease - blood
Hashimoto Disease - complications
Humans
Inflammatory bowel disease
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Pouchitis - complications
Pouchitis - drug therapy
Pouchitis - immunology
Surgery
Surgical anastomosis
Thyroid gland
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Summary:Background and aim Autoimmune disorders (AID) have been shown to be associated with chronic antibiotic-refractory pouchitis (CARP). The role of anti-microsomal antibodies in ileal pouch disorders has not been investigated. The aims of the study were to investigate the prevalence of positive anti-microsomal antibody in symptomatic patients with ileal pouches and to investigate its clinical implications. Methods A total of 118 consecutive symptomatic patients with ileal pouches were included between January and October 2010. Anti-microsomal antibodies were measured at the time of presentation. Demographic, clinical, and laboratory characteristics were compared between patients with positive and negative anti-microsomal antibody. Results There were 14 patients (11.9%) with positive serum anti-microsomal antibody. The mean age of patients in the antibody positive and negative groups were 41.8 ± 14.4 and 42.0 ± 14.0 years, respectively ( p  = 0.189). All 14 patients in the antibody positive group (100%) had some form of AID, as compared to 20 patients (19.2%) in the antibody negative group ( p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-011-1586-7