Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

• Published in: Diabetologia 2011-08, Vol.54 (8), p.2164-2173
• Main Authors: Bernardi, L., Rosengård-Bärlund, M., Sandelin, A., Mäkinen, V. P., Forsblom, C., Groop, P.-H.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Baroreflex - drug effects; Biological and medical sciences; Blood pressure; Chronic obstructive pulmonary disease; Diabetes; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic retinopathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Heart rate; Heart Rate - drug effects; Human Physiology; Humans; Hyperoxia; Hypotheses; Hypoxia; Insulin; Internal Medicine; Intervention; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Ophthalmology; Oxygen - pharmacology; Oxygen - therapeutic use; Retinopathies; Young Adult
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-011-2195-4

Aims/hypothesis We hypothesised that the blunted baroreflex sensitivity (BRS) typical of type 1 diabetes is caused by a higher degree of tissue hypoxia in diabetes, and tested whether oxygen increased BRS and ventilation less, equally or more than in healthy control participants (the latter suggesting higher tissue hypoxia). In addition, we also considered the possible interference between oxygen and breathing pattern. Methods In 96 participants with type 1 diabetes and 40 age-matched healthy controls, we measured BRS (average of six different standard methods), oxygen saturation, end-tidal carbon dioxide and ventilation changes during spontaneous and controlled breathing at 15 and six breaths/min, in normoxia and during 5 l/min oxygen administration. Results BRS was blunted and blood pressure higher in diabetic participants during spontaneous breathing ( p