Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka

Consequences of long-term exposure to diclofenac up to 3 months were evaluated using freshwater crustaceans ( Daphnia magna and Moina macrocopa) and a fish ( Oryzias latipes). Marked decrease of reproduction was observed at 25 mg/L for D. magna, and at 50 mg/L for M. macrocopa. Three-month exposure...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2011-07, Vol.74 (5), p.1216-1225
Main Authors: Lee, Jinyoung, Ji, Kyunghee, Lim Kho, Young, Kim, Pilje, Choi, Kyungho
Format: Article
Language:English
Subjects:
Animal, plant and microbial ecology
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Applied ecology
bioaccumulation
Biological and medical sciences
chronic exposure
Cladocera
Cladocera - drug effects
Crustacea
Daphnia magna
Delay
Diclofenac
Diclofenac - toxicity
Dose-Response Relationship, Drug
Ecotoxicology, biological effects of pollution
eggs
Female
Fertility
Fish
food webs
Foods
Fresh Water - chemistry
Freshwater
Freshwaters
Fundamental and applied biological sciences. Psychology
General aspects
gonadosomatic index
hatching
Invertebrates
Japanese medaka
Long-term exposure
Moina macrocopa
Oryzias - physiology
Oryzias latipes
Parents
Reproduction
Reproduction - drug effects
Surface water
Vitellogenins - metabolism
Water Pollutants, Chemical - toxicity
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Summary:Consequences of long-term exposure to diclofenac up to 3 months were evaluated using freshwater crustaceans ( Daphnia magna and Moina macrocopa) and a fish ( Oryzias latipes). Marked decrease of reproduction was observed at 25 mg/L for D. magna, and at 50 mg/L for M. macrocopa. Three-month exposure of fish to 0.001–10 mg/L of diclofenac resulted in significant decreasing trend in hatching success and delay in hatch. The hatching of the eggs produced from the fish exposed to 10 mg/L was completely interfered, while fertility of the parent generation was not affected. Gonadosomatic index (GSI) of female fish was also affected at 10 mg/L. Predicted no effect concentration of diclofenac was estimated at 0.1 mg/L, which is a few orders of magnitude greater than those observed in ambient water. Therefore direct impact of diclofenac exposure is not expected. However its bioaccumulation potential through food web should warrant further evaluation.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2011.03.014