Efavirenz versus Boosted Atazanavir or Zidovudine and Abacavir in Antiretroviral Treatment-Naive, HIV-Infected Subjects: Week 48 Data from the Altair Study

Background. Antiretroviral therapy is complicated by drug interactions and contraindications. Novel regimens are needed. Methods. This open label study randomly assigned treatment-naive, human immunodeficiency virus (HIV)—infected subjects to receive tenofovir-emtricitabine with efavirenz (Arm I), w...

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Bibliographic Details
Published in:Clinical infectious diseases 2010-10, Vol.51 (7), p.855-864
Main Authors: Puls, Rebekah L., Srasuebkul, Preeyaporn, Petoumenos, Kathy, Boesecke, Christoph, Duncombe, Chris, Belloso, Waldo H., Molina, Jean-Michel, Li, Lin, Avihingsanon, Anchalee, Gazzard, Brian, Cooper, David A., Emery, Sean
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active - adverse effects
Antiretroviral Therapy, Highly Active - methods
Antiretrovirals
Antiviral agents
Atazanavir Sulfate
Benzoxazines - administration & dosage
Benzoxazines - adverse effects
Biological and medical sciences
Blood plasma
Dideoxynucleosides - administration & dosage
Dideoxynucleosides - adverse effects
Drug therapy
Experimentation
Female
Genetic mutation
HIV
HIV - isolation & purification
HIV 1
HIV Infections - drug therapy
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Middle Aged
Oligopeptides - administration & dosage
Oligopeptides - adverse effects
Patients
Pharmacology. Drug treatments
Pyridines - administration & dosage
Pyridines - adverse effects
RNA
RNA, Viral - blood
Studies
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Virology
Viruses
Zidovudine - administration & dosage
Zidovudine - adverse effects
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Summary:Background. Antiretroviral therapy is complicated by drug interactions and contraindications. Novel regimens are needed. Methods. This open label study randomly assigned treatment-naive, human immunodeficiency virus (HIV)—infected subjects to receive tenofovir-emtricitabine with efavirenz (Arm I), with ritonavir-boosted atazanavir (Arm II), or with zidovudine/abacavir (Arm III). Pair-wise comparisons of differences in time-weighted mean change from baseline plasma HIV-RNA to week 48 formed the primary analysis. Treatment arms were noninferior if the upper limit of the 95% confidence interval (CI) was
ISSN:1058-4838
1537-6591
DOI:10.1086/656363