31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients

Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy (31P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-stat...

Full description

Saved in:
Bibliographic Details
Published in:Cephalalgia 2011-09, Vol.31 (12), p.1243-1253
Main Authors: Reyngoudt, Harmen, Paemeleire, Koen, Descamps, Benedicte, De Deene, Yves, Achten, Eric
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Adenosine Triphosphate - metabolism
Adult
Energy Metabolism - physiology
Female
Humans
Magnetic Resonance Spectroscopy
Male
Migraine without Aura - metabolism
Occipital Lobe - metabolism
Phosphates - analysis
Phosphates - metabolism
Phosphocreatine - analysis
Phosphocreatine - metabolism
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy (31P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by 31P-MRS at 3 tesla. Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([Pi]) and magnesium ([Mg2+]) concentrations were not significantly different between MwoA patients and controls. Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102410394675