Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer

High level microsatellite instability (MSI-H) is a hallmark of Lynch syndrome-associated colorectal cancer (CRC). MSI-H CRC express immunogenic tumour antigens as a consequence of DNA mismatch repair deficiency-induced frameshift mutations. Consequently, frameshift antigen-specific immune responses...

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Bibliographic Details
Published in:Familial cancer 2011-09, Vol.10 (3), p.557-565
Main Authors: Bauer, Kathrin, Michel, Sara, Reuschenbach, Miriam, Nelius, Nina, von Knebel Doeberitz, Magnus, Kloor, Matthias
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - immunology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal Neoplasms - immunology
Colorectal Neoplasms - pathology
Dendritic Cells - immunology
Dendritic Cells - pathology
Epidemiology
Female
Human Genetics
Humans
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - pathology
Macrophages - immunology
Macrophages - pathology
Male
Microsatellite Instability
Middle Aged
Prognosis
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - pathology
Young Adult
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Summary:High level microsatellite instability (MSI-H) is a hallmark of Lynch syndrome-associated colorectal cancer (CRC). MSI-H CRC express immunogenic tumour antigens as a consequence of DNA mismatch repair deficiency-induced frameshift mutations. Consequently, frameshift antigen-specific immune responses are commonly observed in patients with Lynch syndrome-associated MSI-H CRC. Dendritic cells (DC) and macrophages play a crucial role in the induction and modulation of immune responses. We here analysed DC and macrophage infiltration in MSI-H and microsatellite-stable CRC. Sixty-nine CRC (MSI-H, n = 33; microsatellite-stable, n = 36) were examined for the density of tumour-infiltrating DC, Foxp3-positive regulatory T cells, and CD163-positive macrophages. In MSI-H lesions, S100-positive and CD163-positive cell counts were significantly higher compared to microsatellite-stable lesions (S100: epithelium P  = 0.018, stroma P  = 0.042; CD163: epithelium P  
ISSN:1389-9600
1573-7292
DOI:10.1007/s10689-011-9449-7