CORRELATION OF ULTRASOUND FINDINGS, LIVER AND SPLEEN CYTOLOGY, AND PROGNOSIS IN THE CLINICAL STAGING OF HIGH METASTATIC RISK CANINE MAST CELL TUMORS

Cytologic sampling of the ultrasonographically normal spleen and liver is not implemented routinely in the clinical staging of canine cutaneous mast cell tumors and normal ultrasound findings are often accepted as sufficient evidence for ruling out splenic or liver metastasis. Our objective was to d...

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Published in:Veterinary radiology & ultrasound 2011-09, Vol.52 (5), p.548-554
Main Authors: BOOK, ALISON P., FIDEL, JANEAN, WILLS, TAMARA, BRYAN, JEFFREY, SELLON, RANCE, MATTOON, JOHN
Format: Article
Language:English
Subjects:
Animals
Cytodiagnosis - veterinary
dog
Dog Diseases - diagnosis
Dog Diseases - diagnostic imaging
Dogs
fine needle aspiration
Liver - diagnostic imaging
Liver - pathology
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Liver Neoplasms - veterinary
Mast-Cell Sarcoma - diagnostic imaging
Mast-Cell Sarcoma - secondary
Mast-Cell Sarcoma - veterinary
metastasis
Prognosis
Skin Neoplasms - pathology
Skin Neoplasms - veterinary
spleen
Spleen - diagnostic imaging
Spleen - pathology
Splenic Neoplasms - diagnostic imaging
Splenic Neoplasms - secondary
Splenic Neoplasms - veterinary
Ultrasonography
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Summary:Cytologic sampling of the ultrasonographically normal spleen and liver is not implemented routinely in the clinical staging of canine cutaneous mast cell tumors and normal ultrasound findings are often accepted as sufficient evidence for ruling out splenic or liver metastasis. Our objective was to define the specificity and sensitivity of ultrasound findings for diagnosis of mast cell infiltration when verified with cytologic evaluation, and to define the prognostic role of cytologic evaluation of liver and splenic aspirates. Dogs with a diagnosis of clinically aggressive grade II, or grade III mast cell tumor treated with a combination vinblastine/CCNU chemotherapy protocol, were selected retrospectively based on availability of cytologic evaluation of spleen plus or minus liver for staging. Out of 19 dogs, 10 dogs had a grade II tumor and nine a grade III tumor. Seven dogs had mast cell infiltration of the spleen, liver, or both. The sensitivity of ultrasound for detecting mast cell infiltration was 43% for the spleen and 0% for the liver. Dogs with positive cytologic evidence of mast cell infiltration to spleen, liver, or both had significantly shorter survival (100 vs. 291 days) than dogs without evidence of mast cell infiltration (P
ISSN:1058-8183
1740-8261
DOI:10.1111/j.1740-8261.2011.01839.x