Molybdenum enzymes and molybdenum cofactor in mycobacteria

When intracelluar pathogens enter the host macrophages where in addition to oxidative and antibiotic mechanisms of antimicrobial activity, nutrients are deprived. Human pathogen Mycobacterium tuberculosis is one of macrophage parasitisms, which can replicate and persist for decades in dormancy state...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular biochemistry 2011-10, Vol.112 (10), p.2721-2728
Main Authors: Shi, Tingyu, Xie, Jianping
Format: Article
Language:English
Subjects:
Aldehyde Oxidoreductases - metabolism
Antibiotics
Antimicrobial activity
Bacterial Proteins - metabolism
Carbon
Coenzymes - metabolism
Cofactors
Dormancy
Energy metabolism
Enzymes
Macrophages
Metalloproteins - metabolism
Molybdenum
Molybdenum - metabolism
MOLYBDENUM COFACTOR
MOLYBDENUM ENZYMES
Multienzyme Complexes - metabolism
MYCOBACTERIA
Mycobacterium - enzymology
Mycobacterium - metabolism
Mycobacterium tuberculosis
Nitrate Reductase - metabolism
Nitrogen
Nitrogen sources
Nutrients
Oxidoreductases - metabolism
Parasitism
Pathogens
Pteridines - metabolism
Sulfur
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:When intracelluar pathogens enter the host macrophages where in addition to oxidative and antibiotic mechanisms of antimicrobial activity, nutrients are deprived. Human pathogen Mycobacterium tuberculosis is one of macrophage parasitisms, which can replicate and persist for decades in dormancy state in virulent environments. It is very successful in escaping the killing mechanisms of macrophage. Molybdenum (Mo) enzymes involve in the global carbon, sulfur, and nitrogen cycles by catalyzing important redox reactions. There are several Mo enzymes in mycobacteria and they exert several important physiological functions, such as dormancy regulation, the metabolism of energy sources, and nitrogen source. Pterin‐based Mo cofactor (Moco) is the common cofactor of the Mo enzymes in mycobacteria but the cofactor biosynthesis is nearly an untapped area. The present article discusses the physiological function of Mo enzymes and the structural feature of the genes coding for Moco biosynthesis enzymes in mycobacteria. J. Cell. Biochem. 112: 2721–2728, 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
1097-4644
DOI:10.1002/jcb.23233