Effects of probiotics on experimental short-bowel syndrome

Abstract Background This study was performed to analyze the potential benefits of probiotics on experimental short-bowel syndrome (SBS). Methods Forty-eight male Wistar-Albino rats were used in the study. The animals were divided into 6 groups as follows: control, rats that received probiotics, rats...

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Bibliographic Details
Published in:The American journal of surgery 2011-10, Vol.202 (4), p.461-468
Main Authors: Tolga Muftuoglu, M.A., M.D, Civak, T., M.D, Cetin, S., M.D, Civak, L., M.D, Gungor, O., M.D, Saglam, A., M.D
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Anastomosis
Animals
Biological and medical sciences
Body weight
Colon
Disease Models, Animal
Evaluation
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Ileum
Immunohistochemistry
Intestine
Intestine, Small - pathology
Intestine, Small - physiopathology
Jejunum
Male
Medical sciences
Mitosis
Other diseases. Semiology
Probiotics
Probiotics - administration & dosage
Rats
Rats, Wistar
Rodents
Short Bowel Syndrome - pathology
Short Bowel Syndrome - physiopathology
Short-bowel syndrome
Statistical analysis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Villus
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Summary:Abstract Background This study was performed to analyze the potential benefits of probiotics on experimental short-bowel syndrome (SBS). Methods Forty-eight male Wistar-Albino rats were used in the study. The animals were divided into 6 groups as follows: control, rats that received probiotics, rats that underwent intestinal transection and anastomosis, rats that underwent anastomosis and received probiotics, rats that underwent 75% intestinal resection, and rats that underwent 75% intestinal resection plus received probiotics. Body weight monitoring, intestinal bowel diameter, villus length and crypt depth measurements, goblet cell count, mitosis, and immunohistochemical evaluation were used for the assessment of intestinal proliferation ability. Results Statistical analysis showed a significant difference in villus length, crypt depth, goblet cell count in villus and crypt, mitosis, and immunohistochemical evaluation in the jejunum when the SBS group was compared with the SBS group that received probiotics. There was no significant difference in these parameters in ileum. Conclusions This trial clearly has shown that probiotics had a positive impact on jejunum in the experimental SBS.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2011.03.005