LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

R‐spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R‐spondins bind to the orphan G‐protein‐coupled receptors LGR4 and LGR5 by their Furin domains. Gain‐ and loss‐of‐fu...

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Bibliographic Details
Published in:	EMBO reports 2011-10, Vol.12 (10), p.1055-1061
Main Authors:	Glinka, Andrei, Dolde, Christine, Kirsch, Nadine, Huang, Ya-Lin, Kazanskaya, Olga, Ingelfinger, Dierk, Boutros, Michael, Cruciat, Cristina-Maria, Niehrs, Christof
Format:	Article
Language:	English
Subjects:	Animals Catenin Caveolin Cell Line Cell proliferation Clathrin Clathrin - metabolism EMBO11 EMBO37 Embryo cells Embryogenesis Endocytosis Furin Gene Expression Regulation HEK293 Cells Hep G2 Cells Humans Internalization LGR4 LGR5 Mammalian cells Mice Pattern formation Protein Binding R-spondin Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Scientific Report Scientific Reports Stem cells Thrombospondins - metabolism Wnt Wnt protein Wnt Signaling Pathway Xenopus Xenopus - genetics Xenopus - metabolism Xenopus Proteins - genetics Xenopus Proteins - metabolism
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