RESORPTION OF BETA-TCP AND HA MATERIALS UNDER CONDITIONS SIMILAR TO THOSE IN LIVING ORGANISMS

The kinetics of formation of a newly formed phase of hydroxyapatite (HAp) on two synthetically prepared bone regenerating materials (beta-tricalcium phosphate (TCP) and porous hydroxyapatite (HA)) was examined. In-vitro tests with simulated body fluid (SBF) were performed under a continual flow of f...

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Bibliographic Details
Published in:Ceramics (Praha) 2010-01, Vol.54 (4), p.398-403
Main Authors: Horkavcova, D, Zitkova, K, Rohanova, D, Helebrant, A, Cilova, Z
Format: Article
Language:English
Subjects:
Biomedical materials
Bones
Covering
Diffraction
Hydroxyapatite
Precipitation
Surgical implants
TCP (protocol)
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Summary:The kinetics of formation of a newly formed phase of hydroxyapatite (HAp) on two synthetically prepared bone regenerating materials (beta-tricalcium phosphate (TCP) and porous hydroxyapatite (HA)) was examined. In-vitro tests with simulated body fluid (SBF) were performed under a continual flow of fresh SBF solution in partly and fully filled testing cells. In the case of testing cells partly filled (1/4 of the volume) with TCP and porous HA, the contact between the material and SBF was better and thus also the precipitation of the new phase HAp was faster. BET identified a ten times increase of the (originally very small) TCP surface in both cases of cell filling, indicating precipitation of the HAp phase. For porous HA, the newly formed phase (HAp) could not be identified by SEM/EDS or RTG diffraction as its character was the same as that of the tested material. However, BET analysis demonstrated a decrease in the size of the specific area of the porous HA after its exposure in the SBF solutions in both tests, indicating covering of the material surface with a newly formed HAp phase. Precipitation of the new phase was also confirmed by the increased weight of tested porous HA. The tested materials were not completely covered with the new HAp phase after 13 days of testing and their surface thus remained accessible for further resorption.
ISSN:0862-5468