Phenylethanolamine N-Methyltransferase Gene Promoter Haplotypes and Risk of Essential Hypertension

Background Phenylethanolamine N-methyltransferase gene (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function. Genetic variation in the PNMT promoter is reportedly associated with the risk of essential hypertension in certain population. Metho...

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Bibliographic Details
Published in:American journal of hypertension 2011-11, Vol.24 (11), p.1222-1226
Main Authors: Huang, Cheng, Zhang, Saidan, Hu, Ke, Ma, Qilin, Yang, Tianlun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arterial hypertension. Arterial hypotension
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Case-Control Studies
China - epidemiology
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Haplotypes - genetics
Humans
Hypertension - epidemiology
Hypertension - genetics
Male
Medical sciences
Middle Aged
Phenylethanolamine N-Methyltransferase - genetics
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
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Summary:Background Phenylethanolamine N-methyltransferase gene (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function. Genetic variation in the PNMT promoter is reportedly associated with the risk of essential hypertension in certain population. Methods In the present study, we explored the association of two common PNMT promoter single-nucleotide polymorphisms (SNPs) G-367A (rs3764351) and G-161A (rs876493) and their haplotypes with the risk of essential hypertension in a Han Chinese population, using 316 pairs of age-, sex-, and geographically matched essential hypertension patients and normotensive controls. Results No significant difference in allele and genotype frequencies at either G-367A (rs3764351) or G-161A (rs876493) was observed between essential hypertension patients and normotensive controls. However, the 2-SNP AA haplotype was found significantly more common in normotensive controls than in essential hypertensive patients (P = 0.01; adjusted odds ratios, 0.17; 95% confidence interval, 0.05-0.58). Conclusions The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. This is the first evidence of an association between a PNMT promoter haplotype and the risk of essential hypertension. American Journal of Hypertension (2011); doi:10.1038/ajh.2011.124
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1038/ajh.2011.124