The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial

Abstract One of the proposed causes of obesity and metabolic syndrome is the excessive intake of products containing added sugars, in particular, fructose. Although the ability of excessive intake of fructose to induce metabolic syndrome is mounting, to date, no study has addressed whether a diet sp...

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Published in:Metabolism, clinical and experimental clinical and experimental, 2011-11, Vol.60 (11), p.1551-1559
Main Authors: Madero, Magdalena, Arriaga, Julio C, Jalal, Diana, Rivard, Christopher, McFann, Kim, Pérez-Méndez, Oscar, Vázquez, Armando, Ruiz, Arturo, Lanaspa, Miguel A, Jimenez, Carlos Roncal, Johnson, Richard J, Lozada, Laura-Gabriela Sánchez
Format: Article
Language:English
Subjects:
Achievement
Adult
Algorithms
Biological and medical sciences
Caloric Restriction - methods
Carbohydrates
Diet (effects)
Diet, Reducing - methods
Dietary Carbohydrates - administration & dosage
Dietary Carbohydrates - pharmacology
Dose-Response Relationship, Drug
Endocrinology & Metabolism
Feeding. Feeding behavior
Female
Fructose - administration & dosage
Fructose - pharmacology
Fundamental and applied biological sciences. Psychology
Hormones
Humans
Lipids
Male
Medical sciences
Metabolic diseases
Metabolic Syndrome - etiology
Metabolic Syndrome - prevention & control
Middle Aged
Miscellaneous
Obesity
Obesity - diet therapy
Other metabolic disorders
Patients
Quality of Life
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight control
Weight Loss - drug effects
Weight Loss - physiology
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Summary:Abstract One of the proposed causes of obesity and metabolic syndrome is the excessive intake of products containing added sugars, in particular, fructose. Although the ability of excessive intake of fructose to induce metabolic syndrome is mounting, to date, no study has addressed whether a diet specifically lowering fructose but not total carbohydrates can reduce features of metabolic syndrome. A total of 131 patients were randomized to compare the short-term effects of 2 energy-restricted diets—a low-fructose diet vs a moderate natural fructose diet—on weight loss and metabolic syndrome parameters. Patients were randomized to receive 1500, 1800, or 2000 cal diets according to sex, age, and height. Because natural fructose might be differently absorbed compared with fructose from added sugars, we randomized obese subjects to either a low-fructose diet (
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2011.04.001