Early Pregnancy Complicated With Juvenile Granulosa Cell Tumor

• Published in: The American journal of the medical sciences 2011-11, Vol.342 (5), p.435-437
• Main Authors: Xu, Hongmei, MD, Shu, Chang, MD, Li, Na, MD, Xia, Meihui, MD, Li, Tingting, MD, Zhong, Yanping, MD, Yan, Xu, MD, Wang, Hong, MD, Zhang, Haipeng, MD, He, Jin, MD
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Female; Female genital diseases; General aspects; Granulosa Cell Tumor - pathology; Granulosa Cell Tumor - surgery; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Juvenile granulosa cell tumors; Medical sciences; Ovarian carcinoma; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Pregnancy; Pregnancy Complications, Neoplastic - pathology; Pregnancy Complications, Neoplastic - surgery; Treatment Outcome; Tumors
• ISSN: 0002-9629; 1538-2990
• DOI: 10.1097/MAJ.0b013e318229992c

Abstract Introduction Granulosa cell tumors (GCTs) are extremely rare tumors and are divided into 2 types: adult (AGCT) and juvenile (JGCT). The JGCTs represent only 5% of all cases. The incidence of ovarian carcinoma diagnosed during pregnancy varies about 0.0179 to 0.11 per 1000 pregnancies. Case A 24-year-old woman at 12 weeks and 3 days of pregnancy was admitted to the authors’ hospital due to a pelvic mass. Surgical exploration revealed a smooth, solid, mobile and well-encapsulated left ovarian mass. Histological and immunohistochemical findings led to the diagnosis of a well-differentiated JGCT. Pregnancy continued uncomplicated and she delivered a healthy baby girl at 37 weeks gestation. About 9 months after the original diagnosis, the patient showed no evidence of disease. Conclusion Treatment options and a review of the literature related to JGCTs are discussed.