Peritoneal carcinomatosis of colon cancer origin: Highest incidence in women and in patients with right-sided tumors

• Published in: Journal of surgical oncology 2011-12, Vol.104 (7), p.792-797
• Main Authors: Sjo, Ole Helmer, Berg, Marianne, Merok, Marianne Arstad, Kolberg, Matthias, Svindland, Aud, Lothe, Ragnhild A., Nesbakken, Arild
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma - epidemiology; Carcinoma - genetics; Carcinoma - secondary; Case-Control Studies; colon cancer; Colonic Neoplasms - epidemiology; Colonic Neoplasms - pathology; DNA Mutational Analysis; DNA, Neoplasm - analysis; Female; Genes, p53 - genetics; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Mutation; Norway - epidemiology; peritoneal carcinomatosis; Peritoneal Neoplasms - epidemiology; Peritoneal Neoplasms - genetics; Peritoneal Neoplasms - secondary; Prospective Studies; Sex Distribution; TP53 mutation; tumor location
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.21959

Background and Objectives : The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC. Methods : Clinical data from all colon cancer patients admitted in 1993–2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series. Results : In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05). Conclusions : The incidence of PC was higher in right‐sided colon cancer and among women. PC patients were younger than non‐PC patients, and PC was independently associated with TP53 mutation in the primary tumor. J. Surg. Oncol. © 2011 Wiley Periodicals, Inc.