Viscoelastic properties of human cerebellum using magnetic resonance elastography

Abstract Background The cerebellum has never been mechanically characterised, despite its physiological importance in the control of motion and the clinical prevalence of cerebellar pathologies. The aim of this study was to measure the linear viscoelastic properties of the cerebellum in human volunt...

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Bibliographic Details
Published in:Journal of biomechanics 2011-07, Vol.44 (10), p.1909-1913
Main Authors: Zhang, John, Green, Michael A, Sinkus, Ralph, Bilston, Lynne E
Format: Article
Language:English
Subjects:
Adult
Algorithms
Biological and medical sciences
Biomechanics. Biorheology
Brain - physiology
Brain damage
Brain viscoelasticity
Cerebellum - physiology
Elasticity
Elasticity Imaging Techniques - methods
Female
Fundamental and applied biological sciences. Psychology
Humans
Imaging, Three-Dimensional
In vivo measurements
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Mechanical properties
Methods
Oscillometry - methods
Physical Medicine and Rehabilitation
Pressure
Shear modulus
Shear Strength
Standard deviation
Stress, Mechanical
Studies
Tissues, organs and organisms biophysics
Viscosity
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Summary:Abstract Background The cerebellum has never been mechanically characterised, despite its physiological importance in the control of motion and the clinical prevalence of cerebellar pathologies. The aim of this study was to measure the linear viscoelastic properties of the cerebellum in human volunteers using Magnetic Resonance Elastography (MRE). Methods Coronal plane brain 3D MRE data was performed on eight healthy adult volunteers, at 80 Hz, to compare the properties of cerebral and cerebellar tissues. The linear viscoelastic storage ( G′ ) and loss moduli (G ″ ) were estimated from the MRE wave images by solving the wave equation for propagation through an isotropic linear viscoelastic solid. Contributions of the compressional wave were removed via application of the curl-operator. Results The storage modulus for the cerebellum was found to be significantly lower than that for the cerebrum, for both white and grey matter. Cerebrum: white matter (mean±SD) G′ =2.41±0.23 kPa, grey matter G′ =2.34±0.22 kPa; cerebellum: white matter, G′ =1.85±0.18 kPa, grey matter G′ =1.77±0.24 kPa; cerebrum vs cerebellum, p
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2011.04.034