Ultrasound-induced modulations of tetrapeptide hierarchical 1-D self-assembly and underlying molecular structures via sonocrystallization

Ultrasound was observed to modulate either underlying molecular structures or morphologies of tetrapeptide self-assembly from microtapes into nanotapes, nanofibers, and then nanorods with a different period of sonication. Herein, we report the ultrasound-induced modulations of the morphologies and u...

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Bibliographic Details
Published in:Journal of colloid and interface science 2009-09, Vol.337 (1), p.54-60
Main Authors: Ke, Damei, Zhan, Chuanlang, Li, Xiao, Wang, Xi, Zeng, Yi, Yao, Jiannian
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Hierarchical structures
Methyl alcohol
Modulation
Molecular structure
Morphology
Nanocomposites
Nanorods
Nanostructure
Self assembly
Surface physical chemistry
Tetrapeptide
Ultrasound
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Summary:Ultrasound was observed to modulate either underlying molecular structures or morphologies of tetrapeptide self-assembly from microtapes into nanotapes, nanofibers, and then nanorods with a different period of sonication. Herein, we report the ultrasound-induced modulations of the morphologies and underlying molecular structures of tetrapeptide 1-D self-assembly. The self-assembly of the tetrapeptide (TTR108–111) precipitating out of the 1:1 mixed methanol/water is modulated from microtapes into nanotapes, nanofibers, and then bundles of nanorods when subjected to sonication for a period. The sonication-treated and untreated self-assemblies all give a set of equatorial pattern and a series of meridional pattern, indications of a typical “cross-β-structure” as the core structural motif. FTIR data indicate that all the assemblies contain a mixed pattern of β-sheets (dominant) and unstructured conformations (minor), and the relative proportion of unbound structures to β-sheets is as a function of sonication time, suggesting an ultrasound-induced modulation of β-sheet interactions. Accordingly, a possible model regarding a dynamic equilibrium between re-dissolution and re-assembling processes, e.g., a typical sonocrystallization process was proposed for such ultrasound-induced modulations of morphologies and underlying molecular structures.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2009.05.024