Antioxidant status an biomarkers of oxidative stress in dogs with lymphoma

Background: Oxidative stress might play a role in carcinogenesis, as well as impacting morbidity and mortality of veterinary cancer patients. The purpose of this study was to evaluate antioxidant concentrations and biomarkers of oxidative stress in dogs with newly diagnosed lymphoma before treatment...

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Published in:Journal of veterinary internal medicine 2009-03, Vol.23 (2), p.311-316
Main Authors: Winter, J.L, Barber, L.G, Freeman, L, Griessmayr, P.C, Milbury, P.E, Blumberg, J.B
Format: Article
Language:English
Subjects:
alpha-Tocopherol - blood
Animals
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
antioxidants
Antioxidants - metabolism
Biomarkers, Tumor - blood
Cancer
Chemotherapy
Dietary supplements
Dog Diseases - blood
Dog Diseases - drug therapy
Dogs
Female
gamma-Tocopherol - blood
Glutathione Peroxidase - blood
Isoprostanes - blood
lymphoma
Lymphoma - blood
Lymphoma - drug therapy
Lymphoma - veterinary
Male
Malondialdehyde - blood
Nutrition
oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Prospective Studies
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Summary:Background: Oxidative stress might play a role in carcinogenesis, as well as impacting morbidity and mortality of veterinary cancer patients. The purpose of this study was to evaluate antioxidant concentrations and biomarkers of oxidative stress in dogs with newly diagnosed lymphoma before treatment and once in remission, with comparison with healthy controls. Hypothesis: Dogs with lymphoma have increased oxidant and reduced antioxidant concentrations compared with healthy controls, and that these abnormalities normalize once remission is achieved. Animals: Seventeen dogs with lymphoma and 10 healthy controls. Methods: Prospective, observational study. Measures of oxidative stress [malondialdehyde and total isoprostanes (isoP)] and antioxidants [α‐tocopherol, γ‐tocopherol, oxygen radical absorbance capacity (ORAC), and glutathione peroxidase (GSHPx)] were assessed in dogs with newly diagnosed lymphoma before treatment compared with healthy control dogs. The same parameters were measured in the dogs with lymphoma on week 7 of the chemotherapy protocol when all dogs were in remission. Results: At baseline, dogs with lymphoma had significantly lower α‐tocopherol (P
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2009.0273.x